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Drug Guide    A   Atapryl

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   Atapryl

Atapryl
Oral


This medication is used to treat movement disorders caused by Parkinson's disease. It does not cure Parkinson's disease, but it may improve shakiness (tremor), muscle stiffness, loss of normal movement as your dose of other Parkinson's medication wears off (end-of-dose failure), and sudden switching between normal movement and stiffness ("on-off" problems). It may improve your range of motion and ability to walk, dress, and exercise. Selegiline is usually used in combination with other medicines (e.g., levodopa, carbidopa).Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain natural substances in the brain (neurotransmitters such as dopamine, norepinephrine, and serotonin).

 
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Atapryl

Uses
This medication is used to treat movement disorders caused by Parkinson's disease. It does not cure Parkinson's disease, but it may improve shakiness (tremor), muscle stiffness, loss of normal movement as your dose of other Parkinson's medication wears off (end-of-dose failure), and sudden switching between normal movement and stiffness ("on-off" problems). It may improve your range of motion and ability to walk, dress, and exercise. Selegiline is usually used in combination with other medicines (e.g., levodopa, carbidopa).Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain natural substances in the brain (neurotransmitters such as dopamine, norepinephrine, and serotonin).
Notes
  • Do not share this medication with others.

Storage
  • Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may be not appear for up to 12 hours and may include excitement, irritability, restlessness, dizziness, weakness, drowsiness, flushing, sweating, fast heartbeat, headache, confusion, and seizures.

How To Use
  • Take this medication by mouth, usually twice daily with breakfast and lunch.
  • Taking selegiline late in the day may cause trouble sleeping.
  • Dosage is based on your medical condition and response to therapy.
  • The usual highest dose is 5 milligrams twice a day.
  • Do not increase your dose or take it more often than directed.After you have been taking selegiline for 2 or 3 days, your doctor may direct you to lower your levodopa dose.
  • Follow your doctor's instructions closely.
  • Do not stop or change the dose of any of your medications without first talking with your doctor.It may take a few weeks for the full benefits of the drug to be noticed.
  • Do not stop taking this drug without first consulting your doctor.
  • Talk with your doctor if the medication stops working well or if your condition worsens.

Side Effects
  • Dizziness, abdominal pain, dry mouth, nausea, stomach upset, trouble sleeping, and headache may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.If you are taking levodopa, you may experience more side effects from the levodopa (e.g., nausea, shakiness, muscle stiffness, mental/mood changes) because selegiline prevents the breakdown of dopamine.
  • Tell your doctor if you experience more of these side effects.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, loss of balance, mental/mood changes (e.g., agitation, confusion, depression, hallucinations), worsening muscle stiffness/twitching, changes in sexual ability/interest, increased shaking (tremor), swollen ankles/legs, difficulty urinating, unusual weight gain.Tell your doctor immediately if any of these rare but very serious side effects occur: easy bleeding/bruising, black/tarry stools, vomit that looks like coffee grounds.This drug may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal.
  • Many drug and food interactions can increase this risk.
  • (See also Drug Interactions section.) Seek immediate medical attention if any of these serious side effects occur: frequent/severe headache, fast/slow/irregular/pounding heartbeat, chest pain, neck stiffness/soreness, severe nausea/vomiting, sweating/clammy skin (sometimes with fever), widened pupils, vision changes (e.g., double/blurred vision)., sudden sensitivity to light (photophobia).A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking selegiline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: a certain kind of adrenal gland tumor (pheochromocytoma), cerebrovascular disease (e.g., stroke), heart problems (e.g., congestive heart failure, heart attack), high blood pressure, history of severe/frequent headaches, peptic ulcer.Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, diabetes, personal/family history of mental/mood disorders (e.g., schizophrenia, bipolar disorder), family history of high blood pressure, heart disease (e.g., coronary artery disease, history of chest pain), liver disease, history of peptic ulcer, overactive thyroid (hyperthyroidism).This drug may make you dizzy; use caution while engaging in activities requiring alertness such as driving or using machinery.
  • Avoid alcoholic beverages.To minimize dizziness and the risk of fainting, get up slowly when rising from a sitting or lying position.Before having surgery, tell your doctor or dentist you are taking this medication.
  • You may need to stop taking this drug beforehand.
  • Follow your doctor's instructions carefully.Selegiline should be used only when clearly needed during pregnancy.
  • Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur: antidepressants (e.g., TCAs such as amitriptyline/protriptyline, nefazodone, SSRIs such as fluoxetine/paroxetine/sertraline, venlafaxine), appetite suppressants (e.g., diethylpropion, sibutramine), drugs for attention deficit disorder (e.g., atomoxetine, methylphenidate), certain antihistamines (azatadine, carbetapentane, chlorpheniramine), bronchodilators (e.g., albuterol, salmeterol), bupropion, buspirone, carbamazepine, cyclobenzaprine, dextromethorphan, certain drugs for glaucoma (e.g., apraclonidine, brimonidine), certain drugs for high blood pressure (e.g., guanethidine, methyldopa), other MAO inhibitors (furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, tranylcypromine), nasal decongestants (e.g., phenylephrine, pseudoephedrine), certain narcotic medications (e.g., fentanyl, meperidine), street drugs (e.g., MDMA/"ecstasy", LSD, mescaline), stimulants (e.g., amphetamines, ephedrine, epinephrine, phenylalanine), "triptan" migraine drugs (e.g., sumatriptan, rizatriptan), tramadol, tyrosine, tryptophan.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting selegiline.
  • Do not take these medications within the 2 weeks before, during or after treatment with selegiline.
  • If you have been taking fluoxetine, wait at least 5 weeks before starting selegiline.
  • Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking selegiline.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs for diabetes (e.g., glyburide, insulin), drugs for high blood pressure (e.g., beta blockers such as atenolol, clonidine, rauwolfia alkaloids such as reserpine, "water pills"/diuretics such as hydrochlorothiazide), herbal products (e.g., ginseng, ephedra/ma huang).Check the labels on all your medicines (e.g., allergy, cough-and-cold products, diet pills) because they may contain dextromethorphan, decongestants, or stimulants.
  • Ask your pharmacist about the safe use of those products.To prevent a very serious high blood pressure reaction, it is very important that you follow a special diet recommended by your doctor or dietician in order to limit your intake of tyramine while you are taking this medicine.
  • Avoid foods and beverages that are high in tyramine, including: aged cheeses (e.g., bleu, cheddar, parmesan), dried/aged/fermented meats and sausages (e.g., salami, liverwurst), preserved fish (e.g., pickled herring), products containing large amounts of yeast (e.g., concentrated yeast extract, bouillon cubes, powdered soup/gravy, homemade or sourdough bread), fermented foods (e.g., sauerkraut, kim chee), most soybean products (e.g., soy sauce, tofu), broad/fava beans, red wine, sherry, tap beers, vermouth.
  • Limit or avoid foods that are moderate in tyramine, including: avocados, bananas, eggplant, green beans, raisins, raspberries, red plums, spinach, tomatoes, chocolate, cultured dairy products (e.g., buttermilk, yogurt, sour cream), fish eggs, pate, peanuts, coffee, cola, alcohol-free beer, bottled beer, distilled spirits, port, white wine.
  • Consult your doctor or dietician for more details and a complete list of other tyramine-containing foods you should limit or avoid.
  • Seek immediate medical attention if you notice symptoms of very high blood pressure such as unusually fast/slow heartbeat, vomiting, unexplained sweating, headache, chest pain, sudden vision changes, weakness on one side of the body, slurred speech.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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