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Prescription Drug Information, Side Effects & Interactions for acetaminophen With Codeine Codeine/acetaminophen - Oral

Tylenol W/codeine, Acetaminophen W/codeine, Ty-Pap W/codeine

Uses
Acetaminophen With Codeine is a combination of a narcotic (codeine) and a non-narcotic (acetaminophen) used to relieve mild to moderate pain. Codeine works by binding to opioid receptors in the brain and spinal cord, and acetaminophen decreases the formation of prostaglandins, therefore relieving pain.

Storage

Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture.
Do not store in the bathroom.
Keep all medicines away from children and pets.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately.
Symptoms of overdose may include: persistent nausea or vomiting, stomach pain, slow breathing, slow heartbeat, cold/clammy skin, unusual sweating, loss of consciousness, severe nausea, yellowing eyes or skin, dark urine, stomach pain, extreme fatigue.

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How To Use

Take Acetaminophen With Codeine by mouth, as directed by your doctor.
You may take Acetaminophen With Codeine with or without food.
If you have nausea, you may take Acetaminophen With Codeine with food, although doing so may decrease its effectiveness.
Consult your doctor or pharmacist about alternatives for decreasing nausea (e.g., antihistamines, lying down for 1-2 hours with minimal head movement).
The dosage is based on your medical condition and response to therapy.
Pain medications work best in relieving pain before it becomes severe.
Once the pain becomes intense, the medication is not as effective in relieving it.
Use Acetaminophen With Codeine exactly as prescribed.
Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because Acetaminophen With Codeine can be habit-forming.
Also, if used for an extended period of time, do not suddenly stop using Acetaminophen With Codeine without your doctor s approval.
When used for an extended period, Acetaminophen With Codeine may not work as well and may require different dosing.
Talk with your doctor if Acetaminophen With Codeine stops working well.
Children - Your child s dose of Acetaminophen With Codeine is based on weight.
Acetaminophen With Codeine contains acetaminophen.
Do not take more acetaminophen than recommended (see Side Effects section).

Side Effects

Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, flushing, vision changes, or mental/mood changes may occur.
If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Tell your doctor immediately if any of these unlikely but serious side effects occur: slow/irregular breathing, slow/irregular heartbeat, change in the amount of urine.
If you do not have liver problems, the adult maximum dose of acetaminophen is 4 grams (4000 milligrams).
If you take more than the maximum daily amount, it may cause serious (possibly fatal) liver disease.
Tell your doctor immediately if you have any of the following symptoms of liver damage: severe nausea, yellowing eyes or skin, dark urine, stomach pain, extreme fatigue.
An allergic reaction to Acetaminophen With Codeine is unlikely, but seek immediate medical attention if it occurs.
Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.
If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Acetaminophen With Codeine should not be used if you have certain medical conditions.
Before using Acetaminophen With Codeine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., respiratory depression, hypercapnia), severe diarrhea (e.g., pseudomembranous colitis, infectious diarrhea due to toxins).
Before using Acetaminophen With Codeine, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, difficulty urinating (e.g., enlarged prostate, urethral stricture), alcohol use, drug dependency, heart problems (e.g., slow/irregular heartbeat, very low blood pressure), abdominal/stomach problems (e.g., gallbladder disease), lung disease (e.g., asthma, chronic obstructive pulmonary disease), seizure disorders, serious head injury or brain disease, spinal problems (kyphoscoliosis), low thyroid disease (hypothyroidism), adrenal gland problems (Addison s disease), psychiatric problems (toxic psychosis), any allergies (especially to codeine or codeine-like medications, sulfites).
Acetaminophen With Codeine may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
Avoid alcoholic beverages because they may increase the risk of side effects of Acetaminophen With Codeine.
Acetaminophen may cause liver damage.
Daily use of alcohol, especially when combined with acetaminophen, may increase your risk for liver damage.
Check with your doctor or pharmacist for more information.
To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.
Caution is advised when using Acetaminophen With Codeine in the elderly because they may be more sensitive to the side effects of Acetaminophen With Codeine, especially the possible decreased breathing and drowsiness effects.
Acetaminophen With Codeine should be used only when clearly needed during pregnancy.
It is not recommended for use for long periods or in high doses near the expected delivery date because of the potential for fetal harm.
Discuss the risks and benefits with your doctor.
Acetaminophen With Codeine passes into breast milk.
While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Missed Dose

If you miss a dose, use it as soon as you remember.
If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
Do not double the dose to catch up.

Drug Interactions

Acetaminophen With Codeine should not be used with the following medications because very serious interactions may occur: naltrexone.
If you are currently using any of these medications, tell your doctor or pharmacist before starting Acetaminophen With Codeine.
Before using Acetaminophen With Codeine, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: other medications for pain, cimetidine, isoniazid, MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine procarbazine, selegiline, isocarboxazid, tranylcypromine), anti-seizure drugs (e.g., carbamazepine, phenobarbital, phenytoin), anticholinergic drugs/antihistamines (e.g., hydroxyzine, oxybutynin, scopolamine), quinidine.
Also report drugs that cause drowsiness such as: medicine for sleep (e.g., sedatives), tranquilizers, anti-anxiety drugs (e.g., diazepam), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine).
Acetaminophen is an ingredient in many nonprescription products and in some combination prescription medications.
Read the labels carefully before taking other pain relievers, fever reducers, or cold products to see if they also contain acetaminophen.
Consult your pharmacist if you are uncertain if your other prescription or nonprescription products contain acetaminophen.
(Also see adult maximum daily dose information in Side Effects section).
Do not start or stop any medicine without doctor or pharmacist approval.