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Arsenic trioxide is used to treat a type of leukemia (acute promyelocytic leukemia-APL) with specific DNA characteristics (t(15;17) translocation) and who have not responded well to other types of cancer chemotherapy.
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| Overview |
Photos |
How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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trisenox
Uses
Arsenic trioxide is used to treat a type of leukemia (acute promyelocytic leukemia-APL) with specific DNA characteristics (t(15;17) translocation) and who have not responded well to other types of cancer chemotherapy.
Storage
- Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture.
- Do not freeze.
- After mixing and subsequent dilution with IV fluids, this product is stable at room temperature for 24 hours or refrigerated (below 46 degrees F or 8 degrees C) for 48 hours.
- Discard any unused portion of the ampule.
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately.
- Symptoms of overdose may include: seizures, muscle weakness, confusion.
Photos
Trisenox Injection Drug |
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TRISENOX |
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How To Use
- Follow all instructions for proper mixing and dilution with the correct IV fluids.
- If you have questions regarding the use of Trisenox, consult your pharmacist.
- Give Trisenox by vein (IV) over 1 to 2 hours mixed in a dextrose or saline solution (D5W or NS) once daily or as directed by your doctor.
- The dosage and length of treatment is based on your weight, medical condition, and response to therapy.
- Before using, check this product visually for particles or discoloration.
- If either is present, do not use the liquid.
- Do not mix arsenic trioxide with other medications.
- Do not save unused portions for later use.
- Learn how to store and discard needles and medical supplies safely.
- Consult your pharmacist.
Side Effects
- Nausea, vomiting, diarrhea, stomach/abdominal pain, fatigue/weakness, constipation, swelling, cough, rash, itching, headache, or dizziness may occur.
- If any of these effects persist or worsen, notify your doctor.
- Tell your doctor immediately if any of these serious side effects occur: trouble breathing, weight gain, unexplained fever, increased thirst, increased urination, blurred vision, chest pain, pain/redness/swelling at the injection site, nose bleed, bone pain, decreased appetite/weight loss, muscle pain/stiffness, easy bruising or bleeding.
- Tell your doctor immediately if any of these unlikely but serious side effects occur: persistent sore throat, coughing up blood, seizures, bloody stool, sores on the mouth/throat/skin, mental/mood changes, change in amount of urine.
- Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, fast/irregular heartbeat.
- An allergic reaction to Trisenox is unlikely, but seek immediate medical attention if it occurs.
- Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing.
- If you notice any other effects not listed above, contact your doctor or pharmacist.
Precautions
- Tell your doctor your medical history, especially of: heart problems, kidney problems, electrolyte problems (e.g., low potassium or low magnesium levels), any allergies (especially to arsenic).
- Trisenox may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.
- Limit alcoholic beverages.
- Because Trisenox can decrease your immune system function, do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received live vaccines (e.g., oral polio vaccine).
- Use caution with sharp objects like safety razors or nail cutters and avoid activities that may increase the chance of getting cut, bruised, or injured.
- Trisenox is not recommended for use during pregnancy because it may cause fetal harm.
- Consult your doctor for details.
- Trisenox passes into breast milk and may have undesirable effects on a nursing infant.
- Consult your doctor before breast-feeding.
Missed Dose
- If you miss a dose, contact your doctor or pharmacist to establish a new dosing schedule.
Drug Interactions
- Tell your doctor of all prescription and nonprescription medication you may use, especially: amphotericin B, water pills (e.g., furosemide, hydrochlorothiazide), other cancer chemotherapy drugs.
- Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, quinidine, sotalol, moxifloxacin, sparfloxacin.
- Ask your doctor or pharmacist for more details.
- Do not start or stop any medicine without doctor or pharmacist approval.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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