Orfadin

Orfadin Nitisinone - Oral Nitisinone is used, along with dietary restriction of certain amino acids (tyrosine and phenylalanine), to treat a genetic metabolism disorder called hereditary tyrosinemia type 1 (HT-1). This condition, usually seen in children, is caused by a deficiency in an enzyme that metabolizes tyrosine.

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Orfadin images: orfadin prescription drug /side effects/Nitisinone - Oral Orfadin nitisinone : A classic pic 1 orfadin prescription drug /side effects/Nitisinone - Oral Orfadin® (nitisinone): A classic pic 4

Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

orfadin Uses Nitisinone is used, along with dietary restriction of certain amino acids (tyrosine and phenylalanine), to treat a genetic metabolism disorder called hereditary tyrosinemia type 1 (HT-1). This condition, usually seen in children, is caused by a deficiency in an enzyme that metabolizes tyrosine. Storage Store in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C) away from light and moisture. Overdose If overdose is suspected, contact your local poison control center or emergency room immediately. Photos Orfadin nitisinone : A classic Orfadin® (nitisinone): A classic How To Use Take Orfadin by mouth usually twice daily on an empty stomach (at least 1 hour before meals); or as directed by your doctor. The dosage is based on your weight, medical condition, and response to therapy. If you have difficulty swallowing Orfadin, the capsules may be opened and the contents sprinkled into a small amount of water, formula, or applesauce immediately before use. Do not make up a supply in advance. Side Effects Headache, diarrhea, or increased thirst may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: stomach pain, dark urine, yellowing eyes or skin. Tell your doctor immediately if any of these unlikely but serious side effects occur: eye problems (e.g., redness, swelling, burning, vision changes, light sensitivity, or pain). Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: rash, persistent sore throat or fever, easy bruising or bleeding, seizures. If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Tell your doctor your medical history, especially of: other metabolism problems (e.g., porphyria), any allergies. Limit your intake of foods that have a high amount of tyrosine and phenylalanine (e.g., high protein, aspartame). Consult your doctor or a dietician for details on a low protein diet and for information on products that may contain aspartame. Orfadin should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether Orfadin passes into breast milk. Because of the potential risk to the infant, breast-feeding while using Orfadin is not recommended. Missed Dose If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Drug Interactions Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.