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Gemtuzumab ozogamicin is used to treat a certain form of leukemia called acute myeloid leukemia (AML). Leukemia is a form of cancer that affects the white blood cells. Mylotarg works by combining an antibody that is specific for this form of leukemia with a potent anti-cancer antibiotic. It is recommended only for people with AML who are older than 60 years of age or who should not receive other forms of cancer chemotherapy.
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| Overview |
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How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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mylotarg
Uses
Gemtuzumab ozogamicin is used to treat a certain form of leukemia called acute myeloid leukemia (AML). Leukemia is a form of cancer that affects the white blood cells. Mylotarg works by combining an antibody that is specific for this form of leukemia with a potent anti-cancer antibiotic. It is recommended only for people with AML who are older than 60 years of age or who should not receive other forms of cancer chemotherapy.
Storage
- Store the unmixed powder/vials in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C) away from light.
- Once mixed, the vial is good for up to 8 hours if protected from light and stored in the refrigerator.
- After mixing and subsequent dilution with IV fluids, this product must be used immediately after dilution.
- Discard any unused portion of the vial(s).
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately.
Photos
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Mylotarg for Injection Drug |
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Mylotarg(マイロターグ) |
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How To Use
- Follow all instructions for proper mixing and dilution with the correct IV fluids.
- If you have questions regarding the use of Mylotarg, consult your pharmacist.
- Mylotarg must be protected from light (sunlight or fluorescent indoor light) at all times.
- Exposure of Mylotarg to light may make it ineffective.
- Consult your pharmacist for details.
- Give Mylotarg by vein (IV) over 2 hours in a saline solution (NS), usually once every 14 days for a total of 2 doses only; or as directed by your doctor.
- The dosage is based on your body size, medical condition, and response to therapy.
- It is recommended that other medications (acetaminophen, diphenhydramine) be given before, and up to 12 hours after Mylotarg has been given to decrease the risk of certain allergic-like side effects (e.g., chills, fever).
- Mylotarg may contain small particles after it is added to the IV solution.
- It is very important to use an IV filter (in- line filter) when giving Mylotarg.
- Consult your pharmacist for the proper use of the filter.
- Before using, check this product visually for unusual particles or discoloration.
- If either is present, do not use the liquid.
- Learn how to store and discard needles and medical supplies safely.
- Consult your pharmacist.
Side Effects
- Temporary chills or fever (lasting up to 24 hours), nausea, vomiting, headache, rash, fatigue, dizziness, diarrhea, or constipation may occur.
- If any of these effects persist or worsen, notify your doctor promptly.
- Tell your doctor immediately if any of these serious side effects occur: cough, persistent sore throat or fever, easy bruising or bleeding, trouble breathing, sores on the mouth or genitals.
- Tell your doctor immediately if any of these unlikely but serious side effects occur: change in amount of urine, pink or red-colored urine, unusual increase in thirst, one-sided weakness, slurred speech, irregular heartbeat.
- Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: swelling of the mouth/tongue, yellowing eyes or skin, stomach pain, dark urine, swelling, pain.
- If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Tell your doctor your medical history, especially of: liver problems, blood problems (e.g., low blood counts), any allergies (especially to antibiotics similar to calicheamicin).
- Because Mylotarg can decrease your immune system function, do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received live vaccines (e.g., oral polio vaccine).
- Use caution with sharp objects like safety razors or nail cutters and avoid activities that may increase the chance of getting cut, bruised, or injured.
- Mylotarg is not recommended for use during pregnancy.
- Consult your doctor for more details.
- It is not known whether Mylotarg passes into breast milk.
- Because of the potential risk to the infant, breast-feeding while using Mylotarg is not recommended.
Missed Dose
- If you miss a dose or your dose is interrupted, contact your doctor to establish a new dosing schedule.
Drug Interactions
- Tell your doctor of all prescription and nonprescription medication you may use, especially: other cancer chemotherapy drugs.
- Do not start or stop any medicine without doctor or pharmacist approval.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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