methotrexate SodiumMethotrexate-Injection - Drug Information and Side Effects on Drug3k.com


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Overview

Photos

How To Use

Side Effects

Precautions

Missed Dose

Drug Interactions

methotrexate Sodium
Methotrexate Lpf

Uses
Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. Methotrexate Sodium works by interfering with cell growth and by suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.

Storage

Store Methotrexate Sodium at room temperature between 59 to 86 degrees F (15 to 30 degrees C) away from light and moisture.
Do not store in the bathroom.
Keep all medicines away from children and pets.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately.
Symptoms of overdose may include severe nausea and vomiting, and bloody stools.

Photos

METHOTREXATE SODIUM
METHOTREXATE SODIUM

M 14 Methotrexate Sodium
b 572 Methotrexate Sodium

How To Use

Methotrexate Sodium is given by injection by a healthcare professional.
The dose and frequency of use are based on your medical condition and response to therapy.
Follow all directions for proper mixing.
Before using, check Methotrexate Sodium visually for particles or discoloration.
If either is present, do not use the liquid.
If you have questions regarding the use of Methotrexate Sodium, consult the pharmacist.
Methotrexate formulations with preservatives must not be used for high-dose treatment nor injected into the spine (intrathecal).

Side Effects

See also the Warning section.
Nausea, vomiting, stomach pain, drowsiness or dizziness may occur.
If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Tell your doctor immediately if any of these serious side effects occur: mouth sores, diarrhea, fever, fatigue, persistent sore throat, unusual bleeding or bruising, black stools, skin rash, enlarged glands/lymph nodes, dark urine, bone pain, unusual pain and discoloration of the skin.
Tell your doctor immediately if any of these unlikely but serious side effects occur: yellowing of the eyes/skin, change in the amount of urine, chest pain, dry cough, trouble breathing, calf pain/swelling, vision changes, irregular heartbeat, muscle weakness, severe headache, neck stiffness, mental/mood changes, seizures.
Temporary hair loss may occur.
Normal hair growth should return after treatment has ended.
An allergic reaction to Methotrexate Sodium is unlikely, but seek immediate medical attention if it occurs.
Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.
If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Methotrexate Sodium should not be used if you have certain medical conditions.
Before using Methotrexate Sodium, consult your doctor or pharmacist if you have: liver disease, severe kidney disease, severe lung disease (e.g., pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders.
Before using Methotrexate Sodium, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal diseases (e.g., peptic ulcer, ulcerative colitis), kidney disease, any active infection (including chickenpox or recent exposure to it), folic acid deficiency, any allergies.
Methotrexate Sodium may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
Avoid alcoholic beverages.
Methotrexate Sodium may make you more sensitive to the sun.
Avoid prolonged sun exposure, tanning booths or sunlamps.
Use a sunscreen and wear protective clothing when outdoors.
Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.
Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.
Wash your hands well to prevent the spread of infections.
A preservative (benzyl alcohol) which may be found in this product or in the liquid used to mix this product (diluent) can infrequently cause serious problems (sometimes death) if given by injection to an infant during the first months of life (neonatal period).
The risk is greater with lower birth weight infants and is greater with increased amounts of benzyl alcohol.
Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat.
Report these symptoms to the doctor immediately should they occur.
If possible, a preservative-free product should be used when treating neonates.
Caution is advised when using Methotrexate Sodium in children because they may be more sensitive to the side effects of Methotrexate Sodium, especially seizures.
Methotrexate must not be used during pregnancy.
It may cause fetal harm.
If you become pregnant or think you may be pregnant, inform your doctor immediately.
Pregnancy must be avoided, therefore males and females must use reliable form(s) of birth control during and for at least 3 months following the end of methotrexate treatment.
Methotrexate passes into breast milk.
Do not breast-feed while using Methotrexate Sodium due to the risk of harm to the infant.

Missed Dose

It is important to use each dose at the scheduled time.
If you miss a dose, contact your doctor to establish a new dosing schedule.
Do not double-up the dose to catch up.

Drug Interactions

Methotrexate Sodium should not be used with the following medications because very serious interactions may occur: acitretin, asparaginase, live vaccines, NSAIDs (e.g., ibuprofen, naproxen) with high-dose methotrexate therapy for certain cancers, pyrimethamine.
If you are currently using any of these medications, tell your doctor or pharmacist before starting methotrexate.
Before using Methotrexate Sodium, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: aspirin/NSAIDs (e.g., ibuprofen, naproxen), other cancer treatments potentially toxic to the kidney (e.g., cisplatin), digoxin, leflunomide, other drugs potentially toxic to the liver (e.g., azathioprine, sulfasalazine, retinoids such as isotretinoin), penicillins, phenytoin, probenecid, procarbazine, sulfa medications, theophylline.
Certain antibiotics (e.g., chloramphenicol, sulfa, tetracyclines) may interfere with methotrexate blood tests (increase methotrexate blood levels due to protein-binding displacement).
Make sure laboratory personnel and your doctors know you are using any of these types of antibiotics.
Do not start or stop any medicine without doctor or pharmacist approval.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.