Gleevec

Gleevec Imatinib Oral Imatinib is used to treat a type of leukemia (chronic myeloid leukemia or CML) as well as certain intestinal tumors (GISTs).

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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

gleevec Uses Imatinib is used to treat a type of leukemia (chronic myeloid leukemia or CML) as well as certain intestinal tumors (GISTs). Storage Store at controlled room temperature (77 degrees F or 25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15 to 30 degrees C) is permitted. Overdose If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: yellowing eyes and skin, dark urine, change in amount of urine (severe increase or decrease). Photos Gleevec.jpg US Gleevec - Printer-Friendly gleevec.jpg More Good News From Gleevec How To Use Take Gleevec by mouth with a meal and a large glass of water, usually once or twice daily; or take as directed by your doctor. If you have trouble swallowing the tablets whole, you may dissolve your dose in a glass of water or apple juice. The amount of liquid will vary depending on your dose; consult your doctor or pharmacist for more detailed instructions. Stir the mixture well and drink immediately. The dosage is based on your medical condition and response to therapy. Side Effects Nausea, vomiting, diarrhea, swelling (especially in the legs or around the eyes), or muscle cramps may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: joint/muscle pain, stomach pain, severe weakness. Tell your doctor immediately if any of these unlikely but serious side effects occur: trouble breathing, unusual weight gain, easy bruising or bleeding, persistent sore throat or fever. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: yellowing eyes and skin, dark urine, coffee-ground vomit, black stools, one-sided weakness, vision problems, slurred speech, confusion. An allergic reaction to Gleevec is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice any other effects not listed above, contact your doctor or pharmacist. Precautions Tell your doctor your medical history, especially of: liver problems, kidney problems, heart disease, lung disease (e.g., asthma, COPD), other cancer or blood disorders, any allergies. Because Gleevec and/or your medical condition can lower your body s ability to fight an infection, do not touch your eyes or the inside of your nose without first washing your hands. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine. Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured. Gleevec is not recommended for use during pregnancy. Consult your doctor for more details. It is not known whether Gleevec passes into breast milk. Because of the potential risk to the infant, breast-feeding while using Gleevec is not recommended. Consult your doctor before breast-feeding. Missed Dose If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Drug Interactions Tell your doctor of all prescription and nonprescription medication you may use, especially of: other cancer drugs (e.g., tamoxifen), drugs used for HIV (e.g., efavirenz, indinavir, nevirapine, ritonavir), cimetidine, blood thinners (e.g., warfarin), azole antifungals (e.g., itraconazole, ketoconazole), macrolide antibiotics (e.g., clarithromycin, erythromycin), anti-seizure medications (e.g., carbamazepine, phenobarbital, phenytoin), corticosteroids (e.g., prednisone), cholesterol-lowering drugs (e.g., statins such as atorvastatin, lovastatin), cyclosporine, tacrolimus, cisapride, calcium channel blockers (e.g., diltiazem, verapamil), heart rhythm drugs (e.g., amiodarone, quinidine), certain diabetes medications (e.g., glipizide, pioglitazone, troglitazone), rifampin, St. John s wort, NSAIDs (e.g., ibuprofen), antidepressants (e.g., desipramine, fluoxetine, paroxetine), beta-blockers (e.g., carvedilol, propranolol). Do not start or stop any medicine without doctor or pharmacist approval.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.