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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

femring Uses Femring is a female hormone and is usually given to women who no longer produce the proper amount. It is used to reduce menopause symptoms (e.g., hot flashes, vaginal dryness). If you are only being treated for vaginal menopause symptoms, other products such as vaginal creams or tablets should be considered before Femring. Storage Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage from 59 to 86 degrees F (15 to 30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets. Overdose If overdose is suspected, contact your local poison control center or emergency room immediately. Femring may be harmful if swallowed. Symptoms of overdose may include: severe nausea/vomiting or excessive vaginal bleeding. How To Use Wash your hands before and after inserting the ring. Insert the ring into the upper third of the vagina as directed. Generally, the ring is left in place for 3 months and then removed and replaced with a new ring if therapy is continued. Do not leave a ring in place for longer than 3 months. Follow the dosing schedule carefully. Read the Patient Information Leaflet available from your pharmacist and learn all usage instructions in the product package. Ask your doctor or pharmacist if you are unclear about any of the information. When the ring is placed properly, you should not feel it and it will not interfere with sexual intercourse. If the ring moves into the lower part of your vagina, push it back into place with your finger. If the ring falls out of the vagina, rinse the ring with lukewarm water and re-insert. The ring is removed by hooking your finger through the ring and gently pulling it out. Discard the used ring in the trash container. Do not flush it down the toilet. Side Effects Dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, and breast tenderness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. You may develop a vaginal yeast infection while using Femring. If this occurs, consult your doctor or pharmacist for treatment options. You may leave the ring in place if you are treating the vaginal infection locally or topically. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., severe depression, memory loss), calf pain/swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes (e.g., change in contact lens fit, loss of vision), breast lumps, swelling of hands or feet, changes in vaginal bleeding (e.g., spotting, breakthrough bleeding or prolonged bleeding), yellowing of eyes or skin, severe stomach pain or cramping. An allergic reaction to Femring is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Femring should not be used if you have certain medical conditions. Before using Femring, consult your doctor or pharmacist if you have: undiagnosed abnormal vaginal bleeding, certain cancers (e.g., breast cancer, especially non-metastatic type), blood clots, active/recent stroke, heart attack. Before using Femring, tell your doctor or pharmacist your medical history, especially of: family medical history (especially breast lumps and cancer), asthma, diabetes, seizures, migraine headaches, liver disease, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of eyes and skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids, endometriosis), vaginal conditions (e.g., recurring vaginal infections, prolapse, stenosis), cholesterol or lipid problems, gallbladder disease, excessive weight gain, certain blood disorder (porphyria), any allergies. If you will be having surgery or will be confined to a chair or bed for a long period of time (e.g., a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are using Femring. Femring may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Femring may cause a patchy darkening of the skin on the face (melasma). Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding use of sunscreens and protective clothing. Cigarette smoking can increase the chance of blood clots while taking Femring (especially in women over the age of 35). Femring must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Femring may pass into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding while using Femring is not recommended. Missed Dose Not applicable. However, if you have not inserted a new ring after 3 months, contact your doctor to establish a new schedule for using Femring. Drug Interactions Before using Femring, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: other vaginal products, corticosteroids (e.g., prednisone). Also tell your doctor or pharmacist of drugs you may use which affect certain liver enzymes (CYP450-3A4 enzymes) such as: azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, hydantoins (e.g., phenytoin), macrolide antibiotics (e.g., erythromycin, clarithromycin), phenobarbital, rifamycins (e.g., rifampin), ritonavir, St. John s wort. This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use Femring. Do not start or stop any medicine without doctor or pharmacist approval.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.