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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

anergan 50 Promethazine Hcl, Promacot, Adgan Uses Promethazine is used for nausea and vomiting. It is also used for sedation. Storage Store at room temperature away from sunlight and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Overdose If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include shortness of breath, trouble breathing, dry mouth, unusual drowsiness or restlessness, flushing, nightmares, loss of consciousness, and seizures. How To Use Anergan 50 is injected deep into a muscle (intramuscular) or into a vein (intravenous). Ask your doctor or pharmacist for proper use of Anergan 50 if you are uncertain how to use this. Side Effects Constipation, drowsiness, vision changes or dry mouth may occur. If any of these effects persist or worsen, notify your doctor. Unlikely to occur but report promptly: restlessness, muscle stiffness, weakness, difficulty speaking, loss of balance, mask- like facial expression, trembling or shaking, dizziness, lip smacking or other uncontrollable movements, difficulty urinating, skin rash/discoloration. Very unlikely to occur but report promptly: persistent sore throat or fever, unusual bleeding or bruising, stomach pain, yellowing of eyes or skin, dark urine, hot dry skin, vomiting. Anergan 50 may infrequently cause a very serious (rarely fatal) nervous system disorder (neuroleptic malignant syndrome). If you notice any of the following unlikely but very serious side effects, seek immediate medical attention: severe muscle stiffness, mental/mood changes, fever, seizures, irregular/fast heartbeat, increased sweating. Males - in the unlikely event you have a painful, prolonged erection, stop using Anergan 50 and seek immediate medical attention or permanent problems could occur. In the unlikely event you have a serious allergic reaction to Anergan 50, seek immediate medical attention. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Anergan 50 should not be given to a patient who is in a coma. Anergan 50 should not be used if you have certain medical conditions. Before using Anergan 50, consult your doctor or pharmacist if you have: certain lung/breathing problems (e.g., COPD, sleep apnea). Tell your doctor your medical history, especially of: very high or very low blood pressure, liver or heart disease, Reye s syndrome, alcohol or drug dependencies, nervous system problems, blood or immune system disorders (e.g., bone marrow depression), seizures, glaucoma (narrow angle), urinary problems (e.g., enlarged prostate), stomach/bowel problems, allergies (especially drug allergies). Anergan 50 may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Use of alcohol can cause extreme drowsiness. Avoid alcohol use. Anergan 50 may increase sensitivity to sunlight. Avoid prolonged sun exposure and wear a sunscreen and protective clothing when you are exposed to the sun. Anergan 50 can reduce sweating making you more susceptible to heat stroke. Avoid strenuous work or exercise in hot weather. Caution is advised when using Anergan 50 in the elderly because they may be more sensitive to the effects of Anergan 50, especially the drowsiness effect. Caution is advised when using Anergan 50 in children because they may be more sensitive to the effects of Anergan 50, especially the slowed breathing effect. Anergan 50 should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Certain drugs closely related to promethazine (a phenothiazine) are known to be excreted into breast milk and may have undesirable effects on a nursing infant. Therefore breast-feeding while using Anergan 50 is not recommended. Consult your doctor before breast- feeding. Missed Dose If you miss a dose, use it as soon as remembered; do not use if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Drug Interactions Inform your doctor about all the medications you use (both prescription and nonprescription), especially of: sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, barbiturates, epinephrine, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine), drugs which are potentially toxic to the blood or immune systems (e.g., cancer chemotherapy). Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: antihistamines that cause drowsiness (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclic anti-depressants such as amitriptyline), tranquilizers. Many cough-and-cold products contain ingredients that may add a drowsiness effect. Before you use any cough-and-cold medications, ask your doctor or pharmacist about the safe use of those products. Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with promethazine such as: isoniazid (INH), other phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline) among others. Consult your doctor or pharmacist for details. Promethazine can affect the results of certain lab tests, including certain pregnancy and blood sugar tests. Make sure laboratory personnel and your doctors know you use Anergan 50. Do not start or stop any medicine without doctor or pharmacist approval.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.