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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Zoledronic Acid Uses This medication is used to treat high blood calcium levels (hypercalcemia) that may occur with cancer. Zoledronic acid is also used to treat bone problems that may occur with a certain type of cancer (multiple myeloma) and other types of cancer. Zoledronic acid belongs to a class of drugs known as bisphosphonates. It works by reducing the amount of calcium released from your bones into your blood. Notes Do not share this medication with others.Laboratory and/or medical tests (e.g., calcium, phosphate, and magnesium levels, albumin, serum creatinine) will be performed to monitor your progress or check for side effects. Consult your doctor for more details. Storage Store the unmixed vials at room temperature between 56-86 degrees F (13-30 degrees C) away from light and moisture. After mixing with IV fluids, this product should be refrigerated between 36-46 degrees F (2-8 degrees C) and used within 24 hours. Discard the mixed drug after 24 hours. Discard any unused portion of the vial. Keep all medicines away from children and pets. Overdose Symptoms of overdose may include: change/decrease in amount of urine, severe muscle spasms, mental/mood changes, seizures. How To Use Follow all instructions for proper mixing and dilution with the correct IV fluids. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not mix this drug with solutions that contain calcium (e.g., lactated Ringer's solution). If you have questions regarding the use of this medication, consult your pharmacist.Kidney tests should be performed before each dose. Give this medication by vein over at least 15 minutes as directed by your doctor.The dosage is based on your medical condition and response to therapy. The dose should not be greater than 4 milligrams or be given over less than 15 minutes. Doses that are higher than 4 milligrams, doses given too quickly, or previous use of this medication (or related drugs such as alendronate) increase the risk for kidney problems. (See also Side Effects and Precautions sections.) For high calcium levels, one dose is usually given. If needed, a repeat dose may be given after 7 days.For bone problems, use as directed by your doctor.It may take up to 7 days before the full benefit of this drug takes effect.Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details. Side Effects Nausea, stomach pain, vomiting, dizziness, diarrhea, flu-like symptoms (e.g., fever, chills, muscle/joint aches), or pain/redness/swelling at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: increased or severe bone/joint/muscle pain, jaw pain, unusual weakness, unusual tiredness, trouble sleeping, trouble swallowing, eye problems (e.g., "pinkeye"/conjunctivitis), vision problems (e.g., trouble seeing), swelling legs, numb/tingling skin, fast/pounding/irregular heartbeat, chest pain, persistent sore throat with fever, unusual bruising/bleeding, change in the amount of urine, burning/painful urination, mental/mood changes (e.g., agitation, anxiety, confusion).A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Before taking zoledronic acid, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates such as alendronate, risedronate; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, asthma, severe loss of body water (dehydration).Infrequently, serious jawbone problems (osteonecrosis) have occurred in people taking this medication. Most people were also using other medications or had conditions that might have caused the jawbone problem. If you have cancer, anemia, blood clotting disorders, infections/other diseases of the mouth, or poor dental hygiene, see your dentist for a full examination/treatment before you start zoledronic acid. Tell your dentist that you will be taking zoledronic acid, and make sure he or she knows of all your medications, especially corticosteroids (e.g., prednisone) and cancer chemotherapy. Also tell him or her of your entire medical history, especially of any cancer radiation treatments. Consult your dentist for more details.This medication may cause severe kidney problems or kidney failure if given improperly. Consult your doctor or pharmacist for more information. (See also How to Use section.) To help prevent harm to your kidneys, drink plenty of fluids unless otherwise directed by your doctor.This drug may make you dizzy or lightheaded. Use caution while driving, using machinery or doing any other activity that requires alertness. Limit alcoholic beverages.This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.It is not known whether this drug passes into breast milk. Because of possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Missed Dose It is important to receive each dose as scheduled. If you miss a dose, contact your doctor for a new schedule. Drug Interactions Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: mineral supplements (especially those containing calcium, magnesium, or phosphorus).Also tell your doctor or pharmacist of drugs that may be harmful to your kidneys such as: aminoglycoside antibiotics (e.g., gentamicin, tobramycin), amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen), tacrolimus, vancomycin, certain "water pills" (loop diuretics such as bumetanide or furosemide).

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.