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Diphenhydramine injection is an antihistamine used to treat life-threatening allergic reactions (anaphylaxis) along with epinephrine and other treatments. It is also used to relieve symptoms of household allergies, hay fever and the common cold when medication cannot be given by mouth. Common allergy symptoms relieved by antihistamines include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose and sneezing.It is also used to treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth. Diphenhydramine works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine).Diphenhydramine should not be used in newborns or premature infants because of an increased risk of side effects.Diphenhydramine injection is also used alone or with other medications to treat shaking (tremor) and muscle stiffness caused by Parkinson's disease when medication cannot be given by mouth. It may also be used to treat side effects of certain psychiatric drugs such as involuntary movements and muscle stiffness (e.g., EPS). It works by blocking acetylcholine. (See also Uses section.)
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| Overview |
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How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Uses
Diphenhydramine injection is an antihistamine used to treat life-threatening allergic reactions (anaphylaxis) along with epinephrine and other treatments. It is also used to relieve symptoms of household allergies, hay fever and the common cold when medication cannot be given by mouth. Common allergy symptoms relieved by antihistamines include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose and sneezing.It is also used to treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth. Diphenhydramine works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine).Diphenhydramine should not be used in newborns or premature infants because of an increased risk of side effects.Diphenhydramine injection is also used alone or with other medications to treat shaking (tremor) and muscle stiffness caused by Parkinson's disease when medication cannot be given by mouth. It may also be used to treat side effects of certain psychiatric drugs such as involuntary movements and muscle stiffness (e.g., EPS). It works by blocking acetylcholine. (See also Uses section.)
Notes
- Do not take for several days before allergy testing.
- Test results can be affected.Do not share this medication with others.
Storage
- Store at room temperature between 59-86 degrees F (between 15-30 degrees C) away from moisture and light.
- Do not store in the bathroom.
- Do not freeze.
- Keep all medicines away from children and pets.
Overdose
- Symptoms of overdose may include large pupils, flushing, fever, hallucinations, weakness, shaking (tremor), muscle twitching, loss of consciousness, and seizures.
- In children, excitement may occur first, followed by loss of coordination, drowsiness, loss of consciousness, and seizures.
How To Use
- This medication is injected into a vein (IV) no faster than 25 milligrams per minute, or deeply into a muscle as directed by your doctor.
- Be very careful to inject into a vein or muscle and not into the skin or just under the skin.
- If this medication is injected into or just under the skin, it can destroy the skin and tissues around the injection site (necrosis).If you are giving this injection to yourself, be sure you learn the proper technique for injecting this drug.
- Before injecting each dose, clean the injection site with rubbing alcohol.
- Before using, check this product visually for particles or discoloration.
- If either is present, do not use the liquid.
- Follow your doctor's directions carefully.
- Learn how to store and discard needles and medical supplies safely.
- Do not use this medication more often than prescribed.
- Your dosage is based on your medical condition and response to therapy.
- Inform your doctor if your condition does not improve or if it worsens.
Side Effects
- Drowsiness, dizziness, headache, irritability, stomach upset, vision changes (e.g., blurred vision), decreased coordination, or dry mouth/nose/throat may occur.
- These effects may decrease as your body adjusts to the medication.
- If they persist or become bothersome, inform your doctor.To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute.
- Diphenhydramine can dry up and thicken the mucus in your lungs, making it more difficult to breathe and clear your lungs.
- To help prevent this effect, be sure to drink plenty of fluids unless otherwise directed by your physician.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these rare but serious side effects occur: pounding/irregular heartbeat, ringing in the ears, seizure, difficulty urinating.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
- Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before using diphenhydramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., asthma, emphysema), glaucoma, heart problems, high blood pressure, liver disease, mental/mood disorders, seizures, stomach problems (e.g., ulcers, obstruction), overactive thyroid, difficulty urinating (e.g., enlarged prostate, urinary retention).This drug may make you dizzy or drowsy or cause blurred vision.
- Use caution engaging in activities requiring alertness such as driving or using machinery.
- Limit the use of alcohol and certain other drowsiness-causing medications (for more details, see Drug Interactions).
- To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.Caution is advised when using this drug in children because they are more sensitive to the effects of antihistamines.
- This drug can often cause excitement in young children instead of drowsiness.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness, drowsiness and low blood pressure.This medication should be used only when clearly needed during pregnancy.
- Tell your doctor if you are pregnant before using this medication.This drug passes into breast milk and may have undesirable effects on a nursing infant.
- Therefore, breast-feeding is not recommended while using this medication.
- Consult your doctor before breast-feeding.
Missed Dose
- If you miss a dose, use it as soon you remember.
- If it is near the time of your next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
- Do not start, stop or change the dosage of any medicine before checking with them first.Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) for 2 weeks before, during, and 2 weeks after treatment with this medication.
- In some cases a serious, possibly fatal drug interaction may occur.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antispasmodics (e.g., atropine, belladonna alkaloids), drugs for Parkinson's disease (e.g., anticholinergics such as benztropine, trihexyphenidyl), tricyclic antidepressants (e.g., amitriptyline).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., dimenhydrinate), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).
- Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients.
- Ask your pharmacist about the safe use of those products.Check the labels on all your medicines because they may also contain diphenhydramine or other antihistamines (e.g., dimenhydrinate).
- This includes medications taken by mouth or applied to the skin (e.g., anti-itch cream, ointment, spray).
- Ask your pharmacist about the safe use of those products.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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