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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Tretinoin Vesanoid Uses Treats a type of leukemia called acute promyelocytic leukemia (APL). Leukemias are cancers of the blood cells. How To Use APPEARANCE: Liquid Filled Capsule. A nurse or other trained health professional will give you this medicine. Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. This medicine is not for long-term use. Side Effects Call your doctor right away if you notice any of these side effects: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. Blood in your urine, trouble urinating, discomfort when urinating, or a change in how much or how often you urinate. Bone pain. Chest pain, pressure, or tightness, or an uneven heartbeat. Confusion, seizures, or fainting. Dark-colored urine or pale stools. Nausea, vomiting, loss of appetite, pain in your upper stomach. New or worsening coughing, or coughing up blood. New trouble with speaking, walking, or balance. Numbness or weakness in your arm or leg, or in one side of your body. Numbness, tingling, or burning pain in your hands, arms, legs, or feet. Pain in your lower leg (calf). Skin rash. Swelling in your abdomen. Tarry, bloody, or unusually dark colored stools. Unusual bleeding or bruising. Vision problems, severe headache. Wheezing, shortness of breath, or other breathing problems. Yellowing of your skin or the whites of your eyes. Precautions You should not use this medicine if you have had an allergic reaction to tretinoin, isotretinoin, vitamin A, or parabens (preservatives used in some medicines). Do not use this medicine if you are pregnant or plan to become pregnant. Missed Dose This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor for instructions. If you vomit after taking your medicine, call your doctor or pharmacist for instructions. Drug Interactions For women: Using this medicine while you are pregnant can cause very serious birth defects. You must use two forms of birth control for the entire time that you are being treated with this medicine, and for 1 month after you take your last dose of this medicine. Even if you have been unable to become pregnant in the past, or have been through menopause, you should still use birth control unless you have had a hysterectomy. You will need to have a negative pregnancy test to be sure that you are not pregnant before you start using this medicine. You also might need to have pregnancy tests during treatment, depending on your situation. If you think you have become pregnant while using this medicine, tell your doctor right away. Women using this medicine should not breast feed a child. Make sure your doctor knows if you have liver disease, high cholesterol, or high triglycerides (fat in the blood). Tell your doctor if you have a history of heart disease or blood clots. Some people who use this medicine may develop a condition called "retinoic acid-APL (RA-APL) syndrome." You should call your doctor right away if you have a fever, breathing problems, rapid weight gain, or swelling in your hands, ankles, or feet when using this medicine. Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments. This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.