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Tipranavir must be used in combination with other medications to help control your HIV infection, thereby improving your ability to fight other infections and improving your quality of life. It also lowers your risk of getting complications of HIV disease (e.g., opportunistic infections, cancer). Tipranavir belongs to a class of drugs known as protease inhibitors. To be effective, tipranavir must be given with another protease inhibitor, ritonavir.Tipranavir is not a cure for HIV infection, and it does not prevent the spread of HIV to others through sexual contact or blood contamination (e.g., sharing dirty needles).
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| Overview |
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How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Tipranavir
Uses
Tipranavir must be used in combination with other medications to help control your HIV infection, thereby improving your ability to fight other infections and improving your quality of life. It also lowers your risk of getting complications of HIV disease (e.g., opportunistic infections, cancer). Tipranavir belongs to a class of drugs known as protease inhibitors. To be effective, tipranavir must be given with another protease inhibitor, ritonavir.Tipranavir is not a cure for HIV infection, and it does not prevent the spread of HIV to others through sexual contact or blood contamination (e.g., sharing dirty needles).
Notes
- Use "safe sex" practices (e.g., latex condoms).
- Consult your doctor or pharmacist for more details.Do not share this medication with others.Laboratory and/or medical tests (e.g., liver function tests, HIV RNA levels, blood counts, blood cholesterol/triglyceride levels) should be performed periodically to monitor your progress or check for side effects.
- Consult your doctor for more details.Keep all medical and laboratory appointments.
Storage
- Refrigerate unopened bottles of this medication between 36-46 degrees F (2-8 degrees C).
- Once opened, this medication may be stored at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
- Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
- Discard any unused medication after 60 days.
- To help you remember when to discard unused medication, write the date that you open the bottle on the bottle.
- Do not store in the bathroom.
- Keep all medicines away from children and pets.
How To Use
- Read the Patient Information Leaflet provided by your pharmacist before you start using tipranavir and each time you get a refill.
- If you have any questions regarding the information, consult your doctor or pharmacist.Take this medication by mouth with food, usually twice daily or as directed by your doctor.
- High-fat meals may increase the absorption of the medicine into your bloodstream, increasing its effectiveness.
- Swallow whole.
- Do not crush or chew the capsules.Tipranavir must be taken with ritonavir, another protease inhibitor.
- If tipranavir is not taken with ritonavir, your body will not keep enough of this drug in your blood to fight the HIV virus.If you are taking antacids (containing magnesium or aluminum) or a buffered form of didanosine (e.g., chewable/dispersible buffered tablets), take tipranavir at least 2 hours before or 1 hour after these medications.Dosage is based on your medical condition and response to therapy.It is very important to continue taking this medication (and other anti-HIV medications) exactly as prescribed by your doctor.This medication works best when the amount of drug in your body is kept at a constant level.
- Therefore, take this drug at evenly spaced intervals.
- Remember to use it at the same time(s) each day.
- Do not skip any doses.Do not take more or less of this drug than prescribed, or stop taking it (or other HIV medicines) even for a short time, unless directed to do so by your doctor.
- Skipping or changing your dose without approval from your doctor may cause the amount of virus to increase, make the infection more difficult to treat (develop resistance), or worsen side effects.
Side Effects
- See also Warning and Drug Interactions sections.Diarrhea, nausea, drowsiness, dizziness, headache or vomiting may occur.
- If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: depression, tingling of hands/feet, increased thirst, signs of infection (e.g., fever, persistent sore throat), change in the amount of urine.Changes in body fat may occur while you are taking this medication (e.g., increased fat in the upper back and stomach areas, decreased fat in the arms and legs).
- The cause and long-term effects of these changes are unknown.
- Discuss the risks and benefits of therapy with your doctor, as well as the possible role of exercise to reduce this side effect.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
- Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.Tipranavir can commonly cause a mild rash that is usually not serious.
- However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction.
- Therefore, seek immediate medical attention if you develop a rash.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before taking tipranavir, tell your doctor or pharmacist if you are allergic to it; or to sulfa drugs; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
- Before using this medicine, consult your doctor or pharmacist if you have: severe liver disease.Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, blood or bleeding disorders (e.g., hemophilia), other conditions causing an increased risk of bleeding (e.g., injury, surgery), high blood fat levels (cholesterol/triglyceride), other viral infections (chronic hepatitis B or hepatitis C), liver disease (including abnormal liver function tests).This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
- Limit alcoholic beverages.This medication may make you more sensitive to the sun.
- Avoid prolonged sun exposure, tanning booths and sunlamps.
- Use a sunscreen and wear protective clothing when outdoors.This medication should be used only when clearly needed during pregnancy.
- Discuss the risks and benefits with your doctor.It is not known if this medication passes into breast milk.
- Because breast milk can transmit HIV, do not breast-feed.
Missed Dose
- If you miss a dose, take the missed dose as soon as you remember.
- Do not take the missed dose if it is within 2 hours of your next dose.
- In that case, skip the missed dose and resume your usual dosing schedule.
Drug Interactions
- See also How to Use section.Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it.
- Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: artemether, lumefantrine, certain anti-anxiety drugs (benzodiazepines such as midazolam, triazolam), cisapride, certain cholesterol-lowering drugs (lovastatin, simvastatin), eletriptan, eplerenone, ergot-containing drugs (e.g., ergotamine), certain heart rhythm drugs (amiodarone, bepridil, flecainide, propafenone, quinidine), certain antihistamines that do not cause drowsiness (astemizole, terfenadine), pimozide, ranolazine, rifamycins (rifampin), St John's wort, certain azole antifungals (voriconazole).If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting tipranavir.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (anticoagulants such as warfarin, heparins), NSAIDs (e.g., aspirin, ibuprofen, naproxen, sulindac, indomethacin), atorvastatin, other azole antifungals (e.g., fluconazole, itraconazole, ketoconazole), calcium channel blockers (e.g., felodipine), drugs for diabetes (e.g., glipizide, insulin, pioglitazone, repaglinide), disulfiram, fluticasone, other HIV medications (e.g., abacavir, didanosine, zidovudine), drugs that suppress the immune system (e.g., cyclosporine, sirolimus, tacrolimus), drugs for sexual ability problems (e.g., sildenafil, tadalafil, vardenafil), macrolide antibiotics (e.g., clarithromycin), metronidazole, certain narcotic pain medications (e.g., meperidine, methadone), other protease inhibitors (e.g., amprenavir, lopinavir, saquinavir), other rifamycins (e.g., rifabutin, rifapentine), SSRI and other antidepressants (e.g., fluoxetine, sertraline, desipramine, trazodone).This medication may decrease the effectiveness of combination-type birth control pills.
- This can result in pregnancy.
- You may need to use an additional form of reliable birth control while using this medication.
- Consult your doctor or pharmacist for details.
- If you are taking a birth control pill that contains estrogen, you may develop rash while taking tipranavir (see also Side Effects section).
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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