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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Rifampin Uses This medication is used in the treatment of tuberculosis and other infections when the oral form cannot be taken.This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness. Notes Do not share this medication with others.Laboratory and/or medical tests (e.g., LFTs, bilirubin, serum creatinine, complete blood count) may be done before starting this medication and during treatment to monitor your progress or check for side effects. Storage Store the unmixed injection vials away from light and moisture. Avoid high heat (above 104 degrees F or 40 degrees C). After mixing the vials, the solution is further mixed with another solution. Do not use if you notice any precipitate in the solution. Consult your pharmacist for details. Keep all medicines away from children and pets. Overdose Symptoms of overdose may include swelling face/eyes, whole-body itching, orange/red discoloration of skin/eyes, nausea/vomiting, stomach/abdominal pain, increasing tiredness, fainting. How To Use This medication is used by injection into a vein by slow infusion, usually once or twice daily; or use as directed by your doctor. Avoid injecting into a muscle or under the skin.Rifampin is frequently used in combination with other antibiotics to prevent or treat certain kinds of infections (e.g., latent/active tuberculosis, meningococcal disease). Your dose/schedule/treatment length will vary, depending on what you are treated for. Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals, or exactly as directed. Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.Inform your doctor if your condition persists or worsens. Side Effects This drug may cause nausea, menstrual changes, headache, drowsiness, or dizziness. Redness, swelling, and pain at the injection site may occur. If any of these effects persist or worsen, inform your doctor promptly.This medication may produce a harmless, reddish coloration of urine, sweat, saliva, or tears. Soft contact lenses may be permanently stained.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Rifampin may infrequently cause serious liver disease. Though sometimes necessary to completely treat certain infections, combination treatment with other drugs (e.g., isoniazid, pyrazinamide) may increase this risk. Tell your doctor immediately if any of these unlikely but serious side effects occur: flu-like symptoms (fever, chills, headache, muscle aches), change in amount of urine, persistent nausea/vomiting, stomach/abdominal pain, dark urine, yellowing eyes/skin, mental/mood changes (e.g., confusion, unusual behavior), unusual tiredness, easy bruising/bleeding, small red spots on the skin, joint pain/swelling.Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection (oral/vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Before taking rifampin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (e.g., hepatitis), HIV infection, history of alcohol use/abuse.This drug may make you dizzy or drowsy; use caution while engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages.Before having surgery, tell your doctor or dentist that you are using this drug.During pregnancy, this medication should be used only when clearly needed. When this drug is taken during the last few weeks of pregnancy, the risk of bleeding in both mother and infant may be increased. Tell your doctor immediately if you notice any bleeding in your newborn. Discuss the risks and benefits with your doctor.Rifampin passes into breast milk. Consult your doctor before breast-feeding. Missed Dose If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.If you are using this drug on a longer schedule (e.g., twice weekly) and miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Drug Interactions Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: live bacterial vaccines (e.g., oral typhoid, BCG vaccine), certain non-nucleoside reverse transcriptase inhibitors (nevirapine, delavirdine), voriconazole, HIV protease inhibitors (e.g., saquinavir, ritonavir, indinavir).If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting rifampin.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.This drug can speed up the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include: antiarrhythmics (e.g., disopyramide, mexiletine, quinidine), certain anti-cancer drugs (e.g., erlotinib, exemestane, imatinib), anticoagulants (e.g., warfarin, dicumarol), certain anti-infectives (e.g., chloramphenicol, clarithromycin, dapsone, doxycycline, telithromycin, zidovudine, quinolones such as ciprofloxacin), certain antimalarial drugs (e.g., atovaquone, quinine), anti-seizure drugs (e.g., phenytoin, phenobarbital, lamotrigine), aprepitant, azole antifungals (e.g., itraconazole, ketoconazole), benzodiazepines (e.g., diazepam, midazolam), certain drugs to lower blood pressure (e.g., enalapril, certain beta blockers such as metoprolol and carvedilol, calcium channel blockers such as verapamil), caspofungin, corticosteroids (e.g., prednisone), certain oral drugs for diabetes (e.g., tolbutamide, chlorpropamide, repaglinide), digitoxin, certain hormone replacement drugs (e.g., estrogens such as conjugated estrogen, progestins such as medroxyprogesterone), certain drugs to suppress the immune system (e.g., cyclosporine, tacrolimus), certain drugs for mental/mood disorders (e.g., clozapine, haloperidol, tricyclic antidepressants such as amitriptyline), narcotic pain relievers (e.g., morphine, methadone), certain drugs for sleep (e.g., ramelteon, eszopiclone, zopiclone), certain statin drugs to lower cholesterol (e.g., atorvastatin, simvastatin), sulfasalazine, theophylline, thyroid medications (e.g., levothyroxine).This medication may decrease the effectiveness of hormonal birth control pills, increasing the risk of pregnancy and menstrual disorders (e.g., unexpected bleeding/spotting). Women may need to use a non-hormonal form of birth control (e.g., condoms, diaphragm with spermicide, IUD) while taking this medication. Talk with your doctor for more details and to discuss reliable forms of birth control.This medication may interfere with certain laboratory tests (urine screening for opiates, blood serum folate/vitamin B12), possibly causing false test results. Rifampin may also make it harder for your body to get rid of certain chemicals used in gallbladder tests. Make sure laboratory personnel and all your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.