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Oxaliplatin images:

Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Oxaliplatin Uses This medication is used to treat advanced cancer of the colon and rectum. Oxaliplatin is a chemotherapy drug that contains platinum. It is used in combination with other medications to slow or stop cancer cell growth. Notes Laboratory and/or medical tests (e.g., complete blood counts, liver and kidney function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. Storage Store the unmixed vials at room temperature at 77 degrees F (25 degrees C) away from light. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not freeze. Once prepared, this medication is stable for 6 hours at room temperature (59-86 degrees F or 15-30 degrees C) or up to 24 hours when refrigerated (36-46 degrees F or 2-8 degrees C). Overdose Symptoms of overdose may include: severe vomiting, chest pain, shortness of breath, wheezing, very slow heartbeat, numbness/tingling of the arms/legs. How To Use This medication is usually given by infusion into a vein (intravenously-IV) over at least 2 hours by a health care professional. It is usually given every 2 weeks along with other medications (e.g., 5-fluorouracil and leucovorin).Follow all instructions for proper mixing and dilution with the correct IV fluids. Do not use sodium chloride or other chloride-containing IV solutions for the final dilution. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not use needles or IV tubing that contain aluminum because this medication reacts with aluminum. If more than one drug is to be given through the same IV line, flush the IV line before and after use with 5% dextrose in water solution. If you have questions regarding the use of this medication, consult your pharmacist.The dosage is based on your medical condition, body size, and response to therapy. Side Effects Diarrhea, changes in taste, mouth sores, nosebleeds, tiredness, headache, dizziness, or trouble sleeping may occur. Nausea and vomiting may be severe in some patients. Your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Temporary hair loss may infrequently occur. Normal hair growth should return after treatment has ended.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: pain/redness/swelling at the injection site, easy or unusual bruising/bleeding, mental/mood changes (e.g., depression), signs of too much body water loss (e.g., decreased urination, increased thirst, dry mouth), muscle cramps, weakness, pain/redness/swelling of the arms/legs, groin/calf pain, fainting.Oxaliplatin can sometimes affect how your nerves work (peripheral neuropathy). Tell your doctor immediately if you develop: sensitivity to cold, trouble breathing/swallowing/speaking, jaw tightness, strange feeling in your tongue, eye pain, chest pressure, numbness/tingling/"pins and needles" sensation of the hands/feet/mouth/throat.You may lessen these types of nerve problems by avoiding cold drinks and ice and by dressing warmly. Tell your doctor immediately if your nerve problems begin to interfere with your normal daily activities (e.g., walking, writing, eating).Seek immediate medical attention if any of these rare but very serious side effects occur: dry cough, shortness of breath, chest pain, black stools, vomit that looks like coffee grounds, vision changes, seizures, sudden confusion.This medication can lower your body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Before taking oxaliplatin, tell your doctor or pharmacist if you are allergic to it; or to other platinum-containing products (e.g., cisplatin, carboplatin); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, blood disorders, bone marrow problems, nerve disorders.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Wash your hands well to prevent the spread of infections.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, the elderly may be more sensitive to the side effects of this drug, especially diarrhea, loss of too much body water and potassium, low white blood cell count, tiredness, and fainting.This medication must not be used during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is recommended that women of child-bearing age and men using this medication use two effective forms of birth control (e.g., condoms and birth control pills) to prevent pregnancy. Consult your doctor for more information.It is not known if oxaliplatin passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Missed Dose For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule. Drug Interactions Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because very serious interactions may occur: nalidixic acid.If you are currently using the medication listed above, tell your doctor or pharmacist before starting oxaliplatin.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use.Tell your doctor or pharmacist if you are also using other drugs that may be harmful to your kidneys such as: aminoglycosides (e.g., gentamicin, amikacin), amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), tacrolimus, vancomycin.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.