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Drug Guide    N   Nitroglycerin

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   Nitroglycerin

Nitroglycerin
IV


Nitroglycerin injection is used to treat chest pain due to angina or heart attack, congestive heart failure after a heart attack, and high blood pressure during surgery. It is also used to cause low blood pressure needed during certain surgeries. This medication is called a nitrate. It works by relaxing blood vessels, allowing blood to flow more easily and decreasing blood pressure. It also allows more blood to flow to the heart.


 
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Overview Photos How To Use Side Effects Precautions Missed Dose Drug Interactions

Nitroglycerin

Uses
Nitroglycerin injection is used to treat chest pain due to angina or heart attack, congestive heart failure after a heart attack, and high blood pressure during surgery. It is also used to cause low blood pressure needed during certain surgeries. This medication is called a nitrate. It works by relaxing blood vessels, allowing blood to flow more easily and decreasing blood pressure. It also allows more blood to flow to the heart.
Notes
  • Laboratory and/or medical tests (e.g., constant heart and blood pressure monitoring) should be performed to monitor your progress or check for side effects.
  • Consult your doctor for more details.Lifestyle changes such as stress-reduction programs, exercise, stopping smoking, and dietary changes may increase the effectiveness of this medicine.
  • Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Avoid situations that may lead to chest pain (e.g., vigorous exercise, cold air, heavy meals).
  • Discuss with your doctor.

Storage
  • Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.
  • Discard any unused portion.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include: persistent throbbing headache, fainting, confusion, fever, slow/irregular heartbeat, vision changes, severe nausea/vomiting, sweating, shortness of breath, cold/clammy skin, seizures.

How To Use
  • This medication is given only in the hospital by a healthcare professional.
  • It is given slowly into a vein by IV as directed by your doctor.
  • Generally, nitroglycerin is given while your heart and blood pressure are monitored.
  • The dose is based on your age, medical condition, and response to therapy.Follow all instructions for proper mixing and dilution with the correct IV fluids.
  • Use IV bottles and tubing that are specially made for nitroglycerin.
  • If you have questions regarding the use of this medication, consult your pharmacist.Before using, check this product visually for particles or discoloration.
  • If either is present, do not use the liquid.Learn how to store and discard needles and medical supplies safely.

Side Effects
  • Headache, lightheadedness, flushing, dizziness, nervousness, nausea, and vomiting may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Headache generally means that the medication is working.
  • Treat headaches with an over-the-counter pain reliever (e.g., acetaminophen) as directed by your doctor.
  • If the headaches continue or become severe, notify your doctor.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: severe dizziness, fainting, fast/pounding heartbeat with headaches, paleness, sweating, blurred vision, dry mouth.Tell your doctor immediately if any of these rare but very serious side effects occur: worsening chest pain, dark urine, bluish lips/skin/nails, unusual tiredness, severe weakness, irregular heartbeat, seizures.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to any other nitrates; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: severe anemia, certain heart problems (e.g., pericardial tamponade, restrictive cardiomyopathy, constrictive pericarditis).Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure, a severe loss of body water (dehydration), certain heart problems (e.g., recent heart attack, chronic heart failure, cardiomyopathy), increased pressure in the brain (e.g., due to head trauma, cerebral hemorrhage), exposure to nitrates while on the job.To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially dizziness, increased risk of falling, and worsening chest pain.This medication should be used only when clearly needed during pregnancy.
  • Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If your dose is interrupted, notify your doctor or pharmacist immediately.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur: drugs used to treat sexual problems (e.g., sildenafil, tadalafil, vardenafil).If you are currently using any of these medications, tell your doctor or pharmacist before starting nitroglycerin.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alcohol, alteplase, migraine drugs (e.g., ergotamine), water pills/diuretics (e.g., furosemide, hydrochlorothiazide), other drugs for high blood pressure (e.g., beta blockers, calcium channel blockers, ACE inhibitors).Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure, cause a fast heartbeat, or increase chest pain (e.g., pseudoephedrine, phenylephrine, chlorpheniramine, diphenhydramine, clemastine, ibuprofen, naproxen).
  • Ask your pharmacist about the safe use of those products.This product can affect the results of a certain lab test (serum triglycerides).
  • Make sure laboratory personnel and all your doctors know you use this drug.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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