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This medication is used to treat depression. Because of the risk of liver disease, this medication is usually used after trying other drugs. Nefazodone works by helping to restore the balance of certain natural chemicals (neurotransmitters such as serotonin, norepinephrine) in the brain.
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| Overview |
Photos |
How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Nefazodone
Uses
This medication is used to treat depression. Because of the risk of liver disease, this medication is usually used after trying other drugs. Nefazodone works by helping to restore the balance of certain natural chemicals (neurotransmitters such as serotonin, norepinephrine) in the brain.
Notes
- Do not share this medication with others.Psychiatric/medical checkups (and laboratory tests such as liver function tests) must be done periodically to monitor your progress and check for side effects.
- Consult your doctor for more details.
Storage
- Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.
- Do not store in the bathroom.
- Keep all medicines away from children and pets.
Overdose
- Symptoms of overdose may include: nausea, vomiting, extreme drowsiness.
How To Use
- Read the Medication Guide and Patient Information Leaflet provided by your pharmacist before you start using nefazodone and each time you get a refill.
- If you have any questions, consult your doctor or pharmacist.Take this medication by mouth with or without food, usually twice daily or as directed by your doctor.Dosage is based on your medical condition and response to treatment.
- To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose.Take this medication exactly as prescribed.
- Do not increase your dose or take this medication more often than prescribed.
- Your condition will not improve any faster, and the risk of serious side effects may be increased.Use this medication regularly in order to get the most benefit from it.
- To help you remember, take it at the same times each day.It is important to continue taking this medication as prescribed even if you feel well.
- Do not stop taking this medication without consulting your doctor.It may take several weeks before this drug takes effect.
- Tell your doctor if your condition persists or worsens.
Side Effects
- See also Warning section.Dizziness, drowsiness, lightheadedness, nausea, dry mouth, or constipation may occur.
- If any of these effects persist or worsen, tell your doctor or pharmacist promptly.To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes (e.g., blurred vision), confusion, weakness, fainting, seizures, easy bleeding/bruising.Seek immediate medical attention if any of these rare but very serious side effects occur: black stools, vomit that looks like coffee grounds.For males, in the very unlikely event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur.A very serious allergic reaction to this drug is rare.
- However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- See also Warning section.Before taking nefazodone, tell your doctor or pharmacist if you are allergic to it; or to trazodone; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, personal or family history of psychiatric disorder (e.g., bipolar/manic-depressive disorder), personal or family history of suicide attempts, heart/blood vessel disease (e.g., history of stroke/heart attack), loss of too much body water (dehydration), seizures, intestinal ulcers/bleeding (peptic ulcer disease).Before having surgery, tell your doctor or dentist that you are using this medication.This drug may make you dizzy or drowsy.
- Use caution while driving, using machinery, or doing any activity that requires alertness.
- Avoid alcoholic beverages since they can make you dizzy or drowsy and also cause liver disease.Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially dizziness/drowsiness or bleeding.During pregnancy, this medication should be used only when clearly needed.
- Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk.
- Consult your doctor before breast-feeding.
Missed Dose
- If you miss a dose, take it as soon as you remember.
- If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
- Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medications because very serious interactions may occur: carbamazepine, cisapride, eplerenone, ivabradine, pimozide, sibutramine.Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before and during treatment and within 1 week after treatment with this medication.
- In some cases a serious (possibly fatal) drug interaction may occur.Avoid taking eletriptan within 72 hours of taking this medication.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting nefazodone.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alpha blockers (e.g., terazosin), digoxin, drugs removed from your body by certain liver enzymes (e.g., "statin" cholesterol drugs such as simvastatin/lovastatin/atorvastatin, tacrolimus, cyclosporine, buspirone, dasatinib, sunitinib, fentanyl, certain benzodiazepines such as alprazolam/triazolam/diazepam), fluoxetine, medications for high blood pressure, other antidepressants (e.g., trazodone, SSRIs such as fluoxetine), other drugs that can cause bleeding/bruising (e.g., anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., phenytoin), medicine for sleep (e.g., zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, haloperidol).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients.
- Ask your pharmacist about using those products safely.Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) that may increase your risk for bleeding if taken together with this drug.
- Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day).
- Consult your doctor or pharmacist for more details.Also report the use of drugs which might increase seizure risk when combined with nefazodone such as isoniazid (INH), bupropion, phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline), among others.
- Consult your doctor or pharmacist for details.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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