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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Nafarelin Synarel Uses Treats endometriosis and premature puberty (very early sexual development). Storage Store upright at room temperature, away from heat, moisture, and direct light. Keep the medicine from freezing. Keep this and all medicine out of the reach of children. How To Use APPEARANCE: Spray. Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to. To use, tilt your head back slightly. Put the tip of the bottle into your nostril and spray the medicine into your nose. Allow 30 seconds between sprays. Try not to sneeze during or right after using this medicine. For premature puberty, it is important to use this medicine regularly without missing doses. Keep using the medicine until your doctor tells you to stop. For endometriosis, start using this medicine between days 2 and 4 of your menstrual cycle, unless instructed otherwise by your doctor. This medicine is used for a period of six months. It is important to use this medicine regularly without missing doses. Side Effects If you notice these less serious side effects, talk with your doctor: Acne, or skin rash or flaking Breasts becoming smaller (during endometriosis treatment) Dryness of vagina (during endometriosis treatment) Headache, muscle aches (during endometriosis treatment) Hot flashes (during endometriosis treatment) Irritation of the nostrils Loss of interest in sex (during endometriosis treatment) Mood changes Weight gain or fluid retention (during endometriosis treatment) Precautions You should not use this medicine if you have had an allergic reaction to nafarelin, gonadotropin releasing hormone, or other gonadotropin releasing hormone agonists, such as leuprolide (Lupron®) or goserelin (Zoladex®). You should not use this medicine if you have unusual vaginal bleeding, or if you are pregnant or breastfeeding. Missed Dose Use your medicine as soon as possible unless it is almost time for your next dose. Skip the missed dose if it is almost time for your next regular dose. Do not use two doses at the same time. Drug Interactions For premature puberty, your doctor may want to check your progress regularly while you are using this medicine. During the first month of using this medicine for premature puberty, girls may have vaginal bleeding or breast enlargement. This should go away. If you have used this medicine for 2 months or more and still have vaginal bleeding or breast enlargement, tell your doctor. If you get a stuffy nose, and need to use a nasal decongestant, call your doctor. If your doctor tells you to use a decongestant, wait at least 2 hours after using nafarelin to use the decongestant. You should not get pregnant while using this medicine to treat endometriosis. Talk to your doctor about effective methods of birth control to use. If you do get pregnant, tell your doctor right away. If you are using this medicine to treat endometriosis, you should stop having menstrual periods. If you have a period after taking this medicine for more than a month, call your doctor. Make sure your doctor knows if you have a family history of osteoporosis if you are being treated for endometriosis.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.