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This medication is used with other drugs to treat a certain type of cancer (acute lymphocytic leukemia). Mercaptopurine belongs to a class of drugs known as purine antagonists. It works by slowing or stopping the growth of cancer cells.This drug may also be used to treat Crohn's disease, ulcerative colitis, and lymphoblastic lymphoma.
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| Overview |
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How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Mercaptopurine
Uses
This medication is used with other drugs to treat a certain type of cancer (acute lymphocytic leukemia). Mercaptopurine belongs to a class of drugs known as purine antagonists. It works by slowing or stopping the growth of cancer cells.This drug may also be used to treat Crohn's disease, ulcerative colitis, and lymphoblastic lymphoma.
Notes
- Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count, liver function tests) should be performed periodically to monitor your progress or check for side effects.
- Keep all medical/lab appointments.
- Consult your doctor for more details.
Storage
- Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture.
- Do not store in the bathroom.
- Keep all medicines away from children and pets.
Overdose
- Symptoms of overdose may include: sudden or severe nausea/vomiting, sudden/severe diarrhea, dark urine, severe abdominal pain, yellowing eyes/skin.
How To Use
- Take this medication by mouth with or without food with a full glass of water (8 ounces or 240 milliliters), usually once daily or as directed by your doctor.
- Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.
- Doing so may help decrease the risk of side effects (e.g., kidney stones).The dosage is based on your body weight, medical condition and response to treatment.
- Do not increase your dose or take this medication more often than prescribed.
- Your condition will not improve any faster, and the risk of serious side effects may be increased.Since this drug may be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.
- Properly discard any unused medication.
- Ask your pharmacist for details.
Side Effects
- Nausea, vomiting, diarrhea, and loss of appetite may occur.
- Temporary hair loss may also occur.
- Normal hair growth should return after treatment has ended.
- If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, dizziness/fainting, joint pain/swelling, persistent nausea/vomiting, stomach/abdominal pain, tongue/mouth sores or pain, unusual tiredness, dark urine, yellowing eyes/skin.Tell your doctor immediately if any of these rare but very serious side effects occur: change in amount of urine, pain in the lower back/side.This medication can lower the body's ability to fight an infection.
- Tell your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.A very serious allergic reaction to this drug is rare.
- However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching, swelling, dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before taking mercaptopurine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.This medication should not be used if you have a certain medical condition.
- Before taking this medicine, consult your doctor or pharmacist if a certain drug (thioguanine) did not work for you in the past.
- This may affect how well mercaptopurine works for you.Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood disorders (e.g., anemia, low blood cell counts), gout, kidney disease (including kidney stones), liver disease, pancreatitis, radiation treatment.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.Wash your hands well to prevent the spread of infections.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.If you need to have surgery or a dental procedure, tell your doctor or dentist that you are using mercaptopurine.Drinking alcohol may increase the risk of stomach/esophageal irritation or liver damage.
- Limit alcoholic beverages.People with a certain inherited problem (lack of thiopurine methyltransferase-TPMT enzyme) may be at increased risk for serious side effects from this medication and may require dosage adjustment.
- Consult your doctor for details and to discuss whether you should be tested for this inherited problem.Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the liver and bone marrow effects.This medication is not recommended for use during pregnancy.
- It may harm the unborn baby.
- It may be particularly harmful during the first 3 months of pregnancy.
- Consult your doctor for more details and to discuss reliable forms of birth control.
- If you become pregnant or think you may be pregnant, tell your doctor immediately.It is not known whether this drug passes into breast milk.
- Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
- Consult your doctor before breast-feeding.
Missed Dose
- If you miss a dose, take it as soon as you remember.
- If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
- Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used within 2 weeks of receiving a live vaccine (e.g., flu, measles, mumps, polio).
- Before taking this medication, tell your doctor of any planned or recently received vaccines.
- (See also Precautions section.)This drug should not be used with the following medication because a very serious interaction may occur: azathioprine.If you are currently using the medication listed above, tell your doctor or pharmacist before starting mercaptopurine.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: aminosalicylates (e.g., olsalazine, mesalazine, sulfasalazine), "blood thinners" (e.g., warfarin), drugs that may affect the bone marrow (e.g., trimethoprim/sulfamethoxazole, other cancer chemotherapies), drugs that may affect the liver (e.g., amiodarone, erythromycin).Before using this medication, tell your doctor or pharmacist if you are taking allopurinol.
- The dose of mercaptopurine may need to be decreased to avoid severe side effects.This product can affect the results of certain lab tests (e.g., uric acid), possibly causing false test results.
- Make sure laboratory personnel and all your doctors know you use this drug.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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