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Isoniazid-Rifamp-Pyrazinamide images:

Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Isoniazid-Rifamp-Pyrazinamide Uses This medication is a combination of 3 medicines (rifampin, isoniazid, pyrazinamide). This combination product should only be used if your doctor determines that the doses of each drug in this product are right for your condition. This medication is used to treat active tuberculosis (TB) of the lungs. These medicines belong to a class of drugs known as antibiotics that are active against tuberculosis. Notes Do not share this medication with others.Keep all medical and laboratory appointments.Laboratory and/or medical tests (e.g., TB cultures, liver function tests, blood cell counts, blood chemistries) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.This medication may interfere with certain laboratory tests (including blood folate/B12, certain acetone/ketone urine tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Storage Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Overdose Symptoms of overdose may include: nausea/vomiting, slurred speech, blurred vision, hallucinations, trouble breathing, fainting, inability to wake up (coma), severe/persistent seizures. How To Use Take this medication by mouth without food, usually once daily or as directed by your doctor. This medication is usually taken for the first 2 months of a 6-9 month treatment course.Dosage is based on your age, weight, medical condition, and response to therapy.It is very important to continue taking this medication (and other TB medications) exactly as prescribed by your doctor.This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it same time each day Do not take more or less of this drug than prescribed or stop taking it (or other TB medicines) even for a short time unless directed to do so by your doctor. Skipping or changing your dose without approval from your doctor may cause the amount of TB bacteria to increase, make the infection more difficult to treat (resistant), or worsen side effects. If TB becomes resistant to this medication, it might also be resistant to other TB medications.Your doctor may also direct you to take vitamin B6 (pyridoxine) to help prevent certain side effects (nerve problems) from isoniazid.Inform your doctor if your condition persists or worsens. Side Effects See also Warning section.Tingling/numbness in the hands/feet, headache, aching joints, diarrhea, stomach upset/pain, or nausea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: persistent nausea/vomiting, weakness, tiredness, severe or persistent stomach/abdominal pain, dark urine, yellowing eyes/skin, loss of appetite, bloody/pink/cloudy urine, painful/swollen joints, swelling of hands/feet, changes in skin color, increase in the amount of urine, breast enlargement in males.Tell your doctor immediately if any of these rare but very serious side effects occur: vision changes, confusion, seizures, sudden weakness, pale skin, fast breathing, easy bruising/bleeding, new fever, persistent sore throat, chills.This medication may rarely cause a serious immune system problem (systemic lupus erythematosus). Tell your doctor immediately if you experience any of these unlikely but serious side effects: unusual tiredness, joint/muscle aches, unusual fever, butterfly-shaped facial rash, swollen glands, bloody/pink urine, swelling of the feet/ankles.Your doctor may need to order special tests if you experience these symptoms. Keep all laboratory and medical appointments.Tears, saliva, stool, sweat, and urine may be colored red-orange. This effect is harmless, but clothing, dentures, and contact lenses may become permanently stained.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Before taking rifampin/isoniazid/pyrazinamide, tell your doctor or pharmacist if you are allergic to any of these medications; or to other rifamycins (e.g., rifabutin, rifapentine); or if you have any other allergies.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe and persistent liver disease, alcoholism, new liver disease not yet diagnosed, HIV infection, a certain liver/blood condition (porphyria), recent gout attack.Before using this medication, tell your doctor or pharmacist your medical history, especially of: HIV infection, cancer, gout, kidney problems, certain nerve problems (peripheral neuropathy), diabetes, seizures, recent childbirth (in women of African/Latina heritage), illegal injection drug use.If you have diabetes, this product may make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination. Your anti-diabetic medication or diet may need to be adjusted.Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the liver effects.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Drug Interactions Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medications because very serious interactions may occur: acetaminophen, ketoconazole, itraconazole, voriconazole, HIV-protease inhibitors (e.g., indinavir, ritonavir), delavirdine, nevirapine.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting isoniazid.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain other HIV medications (e.g., efavirenz), antacids, clarithromycin, erythromycin, fluoroquinolones (e.g., ciprofloxacin), doxycycline, chloramphenicol, mefloquine, atovaquone, estrogens, tamoxifen, thyroid replacement (e.g., levothyroxine), methadone, warfarin, cyclosporine, tacrolimus, corticosteroids (e.g., prednisone, dexamethasone), phenytoin, lamotrigine, barbiturates (e.g., phenobarbital), calcium channel blockers (e.g., verapamil, nifedipine), propranolol, metoprolol, enalapril, losartan, digoxin, mexiletine, disopyramide, propafenone, theophylline, antidiabetics (e.g., glyburide, glimepiride, repaglinide), simvastatin, fluvastatin, nortriptyline, haloperidol, quetiapine, benzodiazepines (e.g., diazepam, triazolam), buspirone, zolpidem, carbamazepine, phenytoin, valproic acid, probenecid, sulfasalazine, cotrimoxazole, exemestane, gefitinib, sunitinib, imatinib, halothane.This medication may decrease the effectiveness of combination-type birth control pills. This can result in pregnancy. You may need to use an additional form of reliable birth control while using this medication. Consult your doctor or pharmacist for details.If taking antacids, take this medication at least 1 hour before the antacid.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.