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Drug Guide    I   Ibuprofen-Oxycodone

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   Ibuprofen-Oxycodone

Ibuprofen-Oxycodone
Oral


This medication is used for the short-term treatment of moderate to severe pain. It reduces pain and swelling (inflammation). This medication is a combination of a narcotic pain reliever (oxycodone) and a nonsteroidal anti-inflammatory drug (NSAID-ibuprofen).


 
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Overview Photos How To Use Side Effects Precautions Missed Dose Drug Interactions

Ibuprofen-Oxycodone

Uses
This medication is used for the short-term treatment of moderate to severe pain. It reduces pain and swelling (inflammation). This medication is a combination of a narcotic pain reliever (oxycodone) and a nonsteroidal anti-inflammatory drug (NSAID-ibuprofen).
Notes
  • Do not share this medication with others.
  • It is against the law.Laboratory and/or medical tests (e.g., complete blood count, kidney and liver function tests) may be performed to monitor your progress or check for side effects.
  • Consult your doctor for more details.This medication has been prescribed for your current condition only.
  • Do not take it later for another condition unless told to do so by your doctor.
  • A different medication may be necessary in those cases.

Storage
  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include: slowed or shallow breathing, slow heartbeat, excessive drowsiness, persistent dizziness/fainting, cold/clammy skin, limp/weak muscles, seizures, or loss of consciousness.

How To Use
  • Read the Medication Guide and Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill.
  • If you have any questions regarding the information, consult your doctor or pharmacist.Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.
  • Do not lie down for at least 30 minutes after taking this drug.
  • If stomach upset occurs while taking this medication, take it with food, milk, or an antacid.Dosage and duration are based on your medical condition and response to therapy.
  • Take this medication exactly as directed by your doctor.
  • To minimize the risk of side effects (e.g., stomach bleeding), the manufacturer recommends using no more than four tablets per day for the shortest possible time (usually no more than 7 days).
  • If you are instructed to take this medication for more than 7 days, discuss the risks and benefits with your doctor.
  • Also follow your doctor's or pharmacist's instruction for the safe use of other non-narcotic pain relievers (e.g., acetaminophen).
  • Consult your doctor or pharmacist if you have any questions regarding your treatment.If you are taking this medication on an as-needed basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur.
  • If you wait until the pain has significantly worsened, the medication may not work as well.This medication may cause dependence, especially if it has been used regularly for an extended period of time, or if it has been used in high doses.
  • In such cases, if you suddenly stop this drug, withdrawal reactions may occur.
  • Such reactions can include anxiety, irritability, sweating, trouble sleeping, or diarrhea.
  • Report any such reactions to your doctor immediately.
  • When stopping extended, regular treatment with this drug, gradually reducing the dosage as directed will help prevent withdrawal reactions.
  • Consult your doctor or pharmacist for more details.Though it is very unlikely to occur, this medication can also result in abnormal drug-seeking behavior (addiction/habit-forming).
  • Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed.
  • Properly stop the medication when so directed.
  • This will lessen the chances of becoming addicted.When used for an extended period, this medication may not work as well and may require different dosing.
  • Talk with your doctor if this medication stops working well.Inform your doctor if your pain persists or worsens.

Side Effects
  • See also Warning section.Nausea, vomiting, constipation, dizziness, drowsiness, upset stomach, or weakness may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise.
  • Consult your pharmacist for help in the use of a laxative (e.g., stimulant-type and stool softener).Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: slow/irregular/shallow breathing, dizziness upon standing, fainting, swelling of the hands or feet, sudden or unexplained weight gain, fast/pounding heartbeat, persistent/severe headache, mental/mood changes, difficult/painful swallowing.Tell your doctor immediately if any of these rare but very serious side effects occur: change in amount of urine, easy bruising or bleeding, signs of infection (e.g., fever, persistent sore throat), severe stomach/abdominal pain, ringing in the ears (tinnitus), unexplained stiff neck, seizures.This drug may rarely cause serious (possibly fatal) liver disease.
  • If you notice any of the following highly unlikely but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: yellowing eyes and skin, dark urine, unusual/extreme tiredness, persistent nausea/vomiting.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking this medication, tell your doctor or pharmacist if you are allergic to oxycodone or ibuprofen; or to other narcotic pain relievers (e.g., codeine, hydrocodone); or to aspirin or other NSAIDs (e.g., naproxen, celecoxib); or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), history of an allergic reaction with symptoms of lip/tongue/throat swelling (angioedema), serious breathing problems (e.g., respiratory depression, severe asthma, hypercarbia), certain bowel diseases (e.g., paralytic ileus), intoxication with medications that depress the nervous system or your breathing (CNS/respiratory depressants such as alcohol or tranquilizers/sedatives), recent heart bypass surgery (CABG).Before using this medication, tell your doctor or pharmacist your medical history, especially of: adrenal gland problems (e.g., Addison's disease), brain disorders (e.g., seizures, head injury, tumor, increased intracranial pressure), blood disorders (e.g., anemia), bleeding or clotting problems, dehydration, high blood pressure, heart diseases (e.g., congestive heart failure, history of heart attack, irregular heartbeat), kidney disease, liver disease, lung diseases (e.g., chronic obstructive pulmonary disease, hypoxia, hypercapnia), asthma, growths in the nose (nasal polyps), gallbladder disease, disease of the pancreas (e.g., pancreatitis), psychiatric problems (e.g., toxic psychosis, depression), spinal problem (kyphoscoliosis), personal or family history of regular use/abuse of drugs/alcohol/other substances, stomach/intestine/esophagus problems (e.g., bleeding, ulcers, recurring heartburn), stroke, swelling (edema, fluid retention), difficulty urinating (e.g., enlarged prostate, urethral stricture), underactive thyroid (hypothyroidism).Before having surgery, tell your doctor or dentist that you are using this medication.This drug may make you dizzy or drowsy; do not drive or operate machinery until you know how this medication affects you.
  • Avoid alcoholic beverages.To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.This medicine may cause stomach bleeding.
  • Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding.
  • Limit alcohol and stop smoking.
  • Consult your doctor or pharmacist for more information.This medication may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths or sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially slow/shallow breathing, stomach bleeding and kidney effects.This medication should be used only when clearly needed during the first 6 months of pregnancy.
  • Discuss the risks and benefits with your doctor.
  • It is not recommended for use during the last 3 months of pregnancy because of the potential for harm to an unborn baby and delay of normal labor/delivery.
  • Use of this medication near or at the time of delivery may have undesirable side effects (e.g., slow/shallow breathing) on the newborn.
  • Consult your doctor for more details.This medication passes into breast milk and may have undesirable effects on a nursing infant.
  • Breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you are prescribed this drug on a regular schedule (not just as-needed) and you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: cidofovir, ketorolac, naltrexone, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine).Avoid using MAO inhibitors within 14 days before or after using this medication.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-platelet drugs (e.g., cilostazol, clopidogrel), oral bisphosphonates (e.g., alendronate), "blood thinners" (e.g., enoxaparin, heparin, warfarin), corticosteroids (e.g., prednisone), cyclosporine, anti-seizure drugs (e.g., carbamazepine, phenobarbital), anticholinergic medications (e.g., atropine, scopolamine), drugs that lower blood pressure (e.g., diuretics such as hydrochlorothiazide and furosemide, ACE inhibitors such as captopril, angiotensin II receptor antagonists such as losartan, and beta-blockers such as metoprolol), other medications for pain (e.g., butorphanol, buprenorphine, pentazocine, tramadol), SSRI antidepressants (e.g., fluoxetine, sertraline), muscle relaxants (e.g., carisoprodol, methocarbamol), pyridostigmine, sodium oxybate, lithium, methotrexate, pemetrexed, probenecid.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: antihistamines that cause drowsiness (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), medicine for sleep (e.g., zolpidem), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers.Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients.
  • Ask your pharmacist about the safe use of those products.Check all prescription and nonprescription medicine labels carefully for other pain/fever drugs (NSAIDs such as aspirin, celecoxib, naproxen).
  • These drugs are similar to ibuprofen, so taking one of these drugs while also taking ibuprofen may increase your risk of side effects.
  • Consult your doctor or pharmacist for more details.However, if your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin.
  • Daily use of ibuprofen may decrease aspirin's ability to prevent heart attack/stroke.
  • Talk to your doctor about using a different medication (e.g., acetaminophen) to treat pain/fever.
  • If you must take ibuprofen, talk to your doctor about possibly taking immediate-release aspirin (not enteric-coated) while also taking the ibuprofen dose apart from your aspirin dose.
  • Do not increase your daily dose of aspirin or change the way you take aspirin/other medications without your doctor's approval.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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