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This combination medication (hydrocodone and ibuprofen) is used for a short time (usually less than 10 days) to treat moderate-to-severe pain. Hydrocodone is a narcotic pain reliever that acts on certain centers in the brain to give you pain relief. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and swelling (inflammation).
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Hydrocodone-Ibuprofen images:
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| Overview |
Photos |
How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Hydrocodone-Ibuprofen
Uses
This combination medication (hydrocodone and ibuprofen) is used for a short time (usually less than 10 days) to treat moderate-to-severe pain. Hydrocodone is a narcotic pain reliever that acts on certain centers in the brain to give you pain relief. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and swelling (inflammation).
Notes
- Do not share this medication with others.
- It is against the law.This medication has been prescribed for your current condition only.
- Do not use it later for another condition unless told to do so by your doctor.
- A different medication may be necessary in that case.Laboratory and/or medical tests (e.g., complete blood count, liver and kidney function tests) may be performed periodically to monitor your progress or check for side effects.
- Consult your doctor for more details.
Storage
- Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.
- Do not store in the bathroom.
- Keep all medicines away from children and pets.
Overdose
- Symptoms of overdose may include: cold/clammy skin, severe stomach pain, vomiting, slow/shallow breathing, slow heartbeat, loss of consciousness, seizures.
How To Use
- Read the Medication Guide provided by your pharmacist before you start using this medication and each time you get a refill.
- If you have any questions, consult your doctor or pharmacist.Take this medication by mouth with or without food, usually every 4 to 6 hours as needed or as directed by your doctor.
- Take it with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.
- Do not lie down for 30 minutes after taking this drug.
- If you have nausea, you may take this drug with food, although this may cause your body to absorb less of the drug and get less benefit from it.
- Consult your doctor or pharmacist about other ways to decrease nausea (e.g., antihistamines, lying down for 1-2 hours with as little head movement as possible).The dosage is based on your medical condition and response to therapy.
- To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time.
- Do not increase your dose, take it more frequently, or take it for a longer time than prescribed.
- The manufacturer recommends you take no more than 5 tablets in a 24-hour period.If you are taking this drug "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur.
- If you wait until the pain has worsened, the medication may not work as well.This medication may cause dependence, especially if it has been used regularly for an extended time or if it has been used in high doses.
- In such cases, withdrawal reactions (e.g., runny nose, watery eyes, anxiety, restlessness, sweating, irritability) may occur if you suddenly stop this drug.
- To prevent withdrawal reactions when stopping extended, regular treatment with this drug, gradually reduce the dosage as directed.
- Consult your doctor or pharmacist for more details, and report any withdrawal reactions immediately.Though very unlikely, abnormal drug-seeking behavior (addiction) is possible with this medication.
- Do not increase your dose, take it more frequently, or take it for a longer time than prescribed.
- Properly stop the medication when so directed.When used for an extended period, this medication may not work as well and may require different dosing.
- Talk with your doctor if this medication stops working well.Inform your doctor if your pain persists or worsens.
Side Effects
- See also Warning section.Upset stomach, nausea, vomiting, constipation, dizziness, or drowsiness may occur.
- If any of these effects persist or worsen, notify your doctor or pharmacist promptly.To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise.
- If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative (e.g., stimulant-type with stool softener).Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: fast/pounding heartbeat, fainting, difficult/painful swallowing, hearing changes (e.g., ringing in the ears), mental/mood changes, persistent/severe headache, slow/shallow breathing, stomach pain, swelling of hands/feet, sudden/unexplained weight gain, vision changes.Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), change in the amount of urine, seizures, unexplained stiff neck.This drug may rarely cause serious, possibly fatal liver disease.
- If you notice any of the following rare but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: yellowing eyes/skin, dark urine, unusual/extreme tiredness, severe stomach/abdominal pain, persistent nausea/vomiting.A very serious allergic reaction to this drug is rare.
- However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching, swelling (especially of throat/face), severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before taking this medication, tell your doctor or pharmacist if you are allergic to ibuprofen or hydrocodone; or to aspirin or other NSAIDs (e.g., naproxen, celecoxib); or to narcotic pain medications (e.g., codeine, morphine); or if you have any other allergies.This medication should not be used if you have certain medical conditions.
- Before using this medicine, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), severe breathing problems (e.g., respiratory depression, hypercapnia), a certain bowel disease (paralytic ileus), intoxication with medications that depress the nervous system or your breathing (CNS/respiratory depressants such as alcohol or tranquilizers/sedatives).Before using this medication, tell your doctor or pharmacist your medical history, especially of: adrenal gland problem (e.g., Addison's disease), asthma, blood disorders (e.g., anemia), bleeding or clotting problem, brain disorders (e.g., seizures, head injury, tumor, increased intracranial pressure), poorly controlled diabetes, gallbladder disease, growths in the nose (nasal polyps), heart problems (e.g., congestive heart failure, irregular heartbeat, recent heart attack), high blood pressure, kidney disease, liver disease, lung diseases (e.g., chronic obstructive pulmonary disease-COPD, hypoxia, hypercapnia), mental/mood disorders (e.g., toxic psychosis), disease of the pancreas (e.g., pancreatitis), a certain spinal problem (kyphoscoliosis), stomach/intestine/esophagus problems (e.g., bleeding, ulcers, recurring heartburn), stroke, swelling of the ankles/feet/hands, a severe loss of body water (dehydration), personal or family history of regular use/abuse of drugs/alcohol, underactive thyroid (hypothyroidism), difficulty urinating (e.g., due to enlarged prostate or urethral narrowing).Before having surgery, tell your doctor or dentist that you are using this medication.This drug may make you dizzy or drowsy.
- Use caution while driving, using machinery, or taking part in any other activity that requires alertness.
- To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
- Limit alcoholic beverages because they may increase the risk of this drug's side effects.This medicine may cause stomach bleeding.
- Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding.
- Limit alcohol and stop smoking.
- Consult your doctor or pharmacist for more information.Caution is advised when this product is used in the elderly because they may be more sensitive to its side effects, especially slow/shallow breathing, stomach bleeding, and kidney effects.During the first 6 months of pregnancy, this medication should be used only when clearly needed.
- It is not recommended for use during the last 3 months of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.
- Use of this medication near or at the time of delivery may have undesirable side effects (e.g., slow/shallow breathing) on the newborn.
- Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk.
- Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
- Consult your doctor before breast-feeding.
Missed Dose
- If you are prescribed this medication on a regular schedule and miss a dose, take it as soon as you remember.
- If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
- Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: cidofovir, ketorolac, naltrexone.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anticholinergic drugs (e.g., atropine, scopolamine), anti-platelet drugs (e.g., cilostazol, clopidogrel), bisphosphonates taken by mouth (e.g., alendronate), "blood thinners" (e.g., enoxaparin, heparin, warfarin), cimetidine, corticosteroids (e.g., prednisone), cyclosporine, digoxin, drugs for high blood pressure (including ACE inhibitors such as captopril, angiotensin II receptor antagonists such as losartan, and beta blockers such as metoprolol), lithium, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), methotrexate, other medications for pain (e.g., codeine, nalbuphine), pemetrexed, probenecid, SSRI antidepressants (e.g., fluoxetine, sertraline), tenofovir, "water pills" (diuretics such as furosemide, hydrochlorothiazide, triamterene).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, psychiatric medicines (e.g., risperidone, amitriptyline, trazodone).Check all prescription and nonprescription medicine labels carefully for other pain/fever drugs (NSAIDs such as aspirin, celecoxib, naproxen).
- These drugs are similar to ibuprofen, so taking one of these drugs while also taking ibuprofen may increase your risk of side effects.
- Consult your doctor or pharmacist for more details.However, if your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin.
- Daily use of ibuprofen may decrease aspirin's ability to prevent heart attack/stroke.
- Talk to your doctor about using a different medication (e.g., acetaminophen) to treat pain/fever.
- If you must take ibuprofen, talk to your doctor about possibly taking immediate-release aspirin (not enteric-coated) while also taking the ibuprofen dose apart from your aspirin dose.
- Do not increase your daily dose of aspirin or change the way you take aspirin/other medications without your doctor's approval.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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