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This medication is used for the short-term treatment of menopause symptoms. It helps reduce episodes of flushing and sweating of the upper body and face, commonly called hot flashes. It also helps treat dryness, itching, and burning around the vagina. These symptoms occur when a woman's body no longer produces the usual amount of female hormone (estrogen) at the age when monthly menstrual periods normally stop. This medication is a combination of 2 hormones, a female hormone (estrogen) and a male hormone (methyltestosterone).If you need treatment only for vaginal menopause symptoms, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
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| Overview |
Photos |
How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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EEMT HS
Uses
This medication is used for the short-term treatment of menopause symptoms. It helps reduce episodes of flushing and sweating of the upper body and face, commonly called hot flashes. It also helps treat dryness, itching, and burning around the vagina. These symptoms occur when a woman's body no longer produces the usual amount of female hormone (estrogen) at the age when monthly menstrual periods normally stop. This medication is a combination of 2 hormones, a female hormone (estrogen) and a male hormone (methyltestosterone).If you need treatment only for vaginal menopause symptoms, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
Notes
- Do not share this medication with others.
- Keep all medical and laboratory appointments.
- You should have a complete physical examination that includes blood pressure measurements and breast/pelvic examinations at regular intervals (e.g., once a year) or as directed by your doctor.
- Follow your doctor's instructions on how to examine your own breasts and report any lumps immediately.
- You should also be regularly screened for cervical cancer (e.g., Pap test) and have periodic mammograms as determined by your doctor.
- Consult your doctor for more details.Lifestyle changes (e.g., reducing stress, eating a low fat/low salt diet, losing weight if you are overweight) to control or prevent high blood pressure, high cholesterol, and diabetes help to prevent heart disease and strokes.
- Keep your mind active with mental exercises to help prevent dementia.
- Discuss with your doctor lifestyle changes that might benefit you.You can also manage hot flashes by keeping a cool body temperature (e.g., using a fan, drinking cool beverages, dressing lightly/in layers, avoiding hot/spicy foods).
- Limiting caffeine and alcohol, exercising regularly, and learning relaxation techniques may help reduce hot flashes.
- Vaginal lubricants can help lessen discomfort during intercourse.
Storage
- Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.
- Do not store in the bathroom.
- Keep all medicines away from children and pets.
Overdose
- Symptoms of overdose may include: severe nausea/vomiting, unusual vaginal bleeding.
How To Use
- Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill.
- If you have any questions, consult your doctor or pharmacist.Take this medication by mouth on a cycle, usually once a day for 21 days followed by no medication for 7 days, or as directed by your doctor.
- Follow your dosing schedule carefully.
- This drug should be used for the shortest possible length of time.
- See also Warning section.This medication may be taken with or without food.
- You may take it with food or immediately after a meal to prevent stomach upset.Take this medication regularly in order to get the most benefit from it.
- Remember to take it at the same time each day as directed.
- Dosage is based on your medical condition and response to therapy.Inform your doctor if your condition does not improve or worsens.
Side Effects
- Dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, or breast tenderness may occur.
- If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., severe depression, memory loss), breast lumps, swelling of hands/feet, unusual vaginal bleeding (e.g., spotting, breakthrough bleeding, prolonged/recurrent bleeding), unusual vaginal discharge/itching/odor, changes in skin color, yellowing eyes/skin, unusual tiredness, stomach/abdominal pain, persistent nausea/vomiting, dark urine, worsening of seizures.Women may experience signs of masculinization (male characteristics) from methyltestosterone.
- To prevent these changes from becoming permanent, stop taking this medication and tell your doctor immediately if any of the following occur: hoarseness, deepening of the voice, facial hair growth, new or worsening acne, an enlarged clitoris, menstrual period changes.This medication may infrequently cause serious problems such as heart attacks, stroke, and blood clots.
- Seek immediate medical attention if you experience any of the following: chest pain, jaw/left arm pain, sudden severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (e.g., double vision, loss of vision), pain/redness/swelling of legs, trouble breathing, coughing up blood, sudden dizziness/fainting.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
- Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before taking this medication, tell your doctor or pharmacist if you are allergic to methyltestosterone or estrogen; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
- Before using this medicine, consult your doctor or pharmacist if you have: vaginal bleeding of unknown cause, certain cancers (e.g., breast cancer, cancer of the uterus or ovaries), blood clots, recent stroke or heart attack (within 1 year), liver problems.Before using this medication, tell your doctor or pharmacist your medical history, especially of: family medical history (especially breast lumps and cancer), asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, past heart attacks, congestive heart failure), past strokes, kidney disease, underactive thyroid (hypothyroidism), mineral imbalance (low or high calcium blood level), mental/mood disorders (e.g., dementia, depression), high blood pressure during pregnancy (toxemia), yellowing eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use, uterus problems (e.g., uterine fibroids, endometriosis), high blood cholesterol/fat (triglyceride) levels, gallbladder disease, obesity, certain blood disorder (porphyria), lupus.If you have diabetes, this medication may make it harder to control your blood sugar levels.
- Monitor your blood sugar regularly as directed by your doctor.
- Tell your doctor the results and of any symptoms such as increased thirst/urination, weakness, or fainting.
- Your anti-diabetic medication or diet may need to be adjusted.This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.
- Limit alcoholic beverages.If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses.
- Contact your eye doctor if these problems occur.This drug may cause a patchy darkening of the skin on the face (melasma).
- Sunlight may worsen this darkening.
- Avoid prolonged sun exposure, tanning booths, and sunlamps.
- Use a sunscreen and wear protective clothing when outdoors.Do not smoke cigarettes or use tobacco.
- Estrogens combined with smoking further increase your risk for stroke, blood clots, high blood pressure, and heart attacks, especially in women older than 35.If you will be having surgery or will be confined to a chair or bed for a long time (e.g., a long plane flight), notify your doctor beforehand.
- Special precautions may need to be taken in these circumstances (such as stopping this medication) because of the increased risk for blood clots.
- Consult your doctor for details.This medication is not meant for use in children.This medication must not be used during pregnancy.
- It may harm the unborn baby.
- If you become pregnant or think you may be pregnant, inform your doctor immediately.This medication is not effective for preventing a miscarriage and should not be used for this purpose.This drug may pass into breast milk and could have undesirable effects on a nursing infant.
- Therefore, breast-feeding is not recommended while using this drug.
- Consult your doctor before breast-feeding.
Missed Dose
- If you miss a dose, take it as soon as you remember.
- If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
- Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: anastrozole, exemestane.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting methyltestosterone/estrogen.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: "blood thinner" (warfarin), corticosteroids (e.g., prednisone), cyclosporine, raloxifene, tamoxifen, drugs affecting liver enzymes that remove estrogens from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, rifamycins including rifabutin, St.
- John's wort, certain anti-seizure medications including carbamazepine, phenobarbital, phenytoin).This product can affect the results of certain lab tests.
- Make sure laboratory personnel and all your doctors know you use this drug.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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