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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Duloxetine Cymbalta Uses Treats depression. Also treats nerve pain caused by diabetes. This medicine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed. Keep all medicine away from children and never share your medicine with anyone. How To Use APPEARANCE: Delayed Release Capsule. Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to. You may take this medicine with or without food. Swallow the delayed-release capsule whole. Do not sprinkle contents of the capsule on food or mix with liquids before you take it. Do not crush, break, open, or chew it. You may need to use this medicine for several weeks before you begin to feel better. Keep using the medicine even if you feel your condition is not improving. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information. Side Effects Call your doctor right away if you notice any of these side effects: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. Aggression, anxiety, anger, or hostility. Dark-colored urine or pale stools. Extreme sleepiness or drowsiness. Fast or uneven heartbeat, dizziness. Feeling confused, nervous, restless, clumsy. Muscle spasms, twitching, or stiffness. Nausea, vomiting, loss of appetite, pain in your stomach. Panic attacks, tremors, or feeling irritable. Severe nausea, diarrhea. Unexplained fever, sweating, shivering. Unusual behavior, or thoughts about hurting yourself. Unusual bleeding or bruising. Unusual tiredness or weakness. Yellowing of your skin or the whites of your eyes. Precautions You should not use this medicine if you have had an allergic reaction to duloxetine, or if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. You should not use this medicine if you have uncontrolled narrow-angle glaucoma. Missed Dose If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose. Drug Interactions Make sure your doctor knows if you are pregnant, trying to become pregnant, or breastfeeding. Tell your doctor if you have heart disease, high blood pressure, narrow-angle glaucoma, kidney disease, liver disease, diabetes, or any digestion problems. Also tell your doctor if you have a history of seizures or mania. For some children and teenagers, this medicine can increase thoughts of suicide. All of the warnings in this leaflet are true for a child or teenager who is using this medicine. Tell your doctor right away if you start to feel more depressed. Also tell your doctor right away if you have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure your caregiver knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let your doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide. Make sure your doctor knows if you have ever abused drugs or alcohol. This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. After you stop using the medicine, call your doctor if you have mood or behavior changes, confusion, headache, nausea, vomiting, seizures, tingling pain, or ringing in your ears.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.