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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Dolasetron Uses This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). It is also used to prevent and treat nausea and vomiting after surgery.Dolasetron belongs to a class of medications called 5-HT3 blockers. It works by blocking one of the body's natural substances (serotonin) that can cause vomiting. Notes Do not share this medication with others. Storage Store the US vial or ampule at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. If diluted with the correct IV fluids, this product is stable at room temperature for 24 hours or refrigerated for 48 hours. Discard any unused diluted medication after 24 hours if at room temperature or after 48 hours if refrigerated.Store the Canadian vial or ampule at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. After dilution with the correct IV fluids, this product should be used immediately or stored in the refrigerator at 36-47 (2-8 degrees C) for no more than 24 hours.If this liquid for injection is diluted with juice to take by mouth, the juice mixture may be kept up to 2 hours at room temperature before use. However, it is safer to mix the medication right before use to prevent accidentally giving the juice mixture into a vein.Do not store in the bathroom. Keep all medicines away from children and pets. How To Use This drug is given into a vein by a health care professional. It is usually given 30 minutes before cancer chemotherapy or before/during/after surgery. The drug may be given directly into a vein over 30 seconds, or it may be mixed in an IV fluid and given into a vein over a longer time (e.g., 5 to 15 minutes).Follow all instructions for proper mixing and dilution with the correct IV fluids. Do not mix dolasetron with other drugs in the same injection or inject other drugs into the same vein at the same time. If you have questions about using this medication properly, consult your pharmacist.Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.Learn how to store and discard needles and medical supplies safely. Dosage is based on your medical condition and response to treatment. The dosage may also be based on weight. The usual maximum dose is 100 milligrams. Use this medication exactly as directed to get the most benefit from it. Do not use more medication or use it more often than prescribed. Ask your doctor or pharmacist if you have questions.If you or your child have trouble swallowing tablets, this liquid product for injection may be mixed in apple or apple-grape juice and taken by mouth. The juice mixture may be kept up to 2 hours at room temperature before use. See also Storage section.When this medication is taken by mouth, it is usually taken within 1 hour before your cancer chemotherapy or within 2 hours before surgery, or as directed by your doctor. This medication may be taken with or without food. However, your doctor may tell you not to eat before chemotherapy or surgery. Follow your doctor's instructions carefully.Tell your doctor if your nausea does not improve or if it worsens. Side Effects Headache, diarrhea, dizziness, or pain/redness/swelling at the injection site may occur. If any of these effects persist or worsen, tell your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach/abdominal pain, vision changes.Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, fainting, slow/fast/irregular heartbeat.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Before using dolasetron, tell your doctor or pharmacist if you are allergic to it; or to other 5-HT3 blockers (e.g., granisetron, ondansetron); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., irregular heartbeat, QT syndrome), low mineral levels (electrolyte imbalances such as low potassium or magnesium), stomach/intestinal problems (e.g., recent surgery, ileus, swelling).This drug may make you dizzy. Use caution while driving, using machinery, or doing any other activity that requires alertness. Avoid alcoholic beverages.To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding. Missed Dose Tell your doctor if you miss your dose or did not use your dose at the correct time before your scheduled chemotherapy appointment or surgery. Your treatment or surgery may need to be rescheduled. Drug Interactions Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: apomorphine, medications that may affect the heart rhythm-QTc prolongation in the EKG (e.g., ziprasidone).If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting dolasetron.Other drugs besides dolasetron that may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, and erythromycin, among others. QTc prolongation can infrequently result in serious (rarely fatal) irregular heartbeat. Consult your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.Before using this medication, tell your doctor of all prescription and nonprescription/herbal products you may use, especially of: atenolol, cimetidine, previous treatment with certain chemotherapy drugs (anthracyclines such as daunorubicin/doxorubicin), "water pills" (diuretics such as furosemide/hydrochlorothiazide).

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.