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Overview	Photos	How To Use	Side Effects	Precautions	Missed Dose	Drug Interactions

Depogen Uses Estradiol is an estrogen hormone used in women who are not producing enough of the hormone naturally. It is used to relieve certain symptoms associated with menopause (e.g., hot flashes, headaches). Notes Long-term or high dose estrogen therapy is suspected in increasing the risk of serious medical conditions such as heart disease, liver disease, gallbladder disorders and endometrial cancer. It is important that you are well informed by reading all the information provided with the medication. Also discuss the risks and benefits of this therapy with your doctor. Keep all regular lab, dental and medical appointments. Storage Store this medication at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light. Safely store and properly discard needles and medical supplies as directed by your care provider. How To Use HOW TO USE THIS MEDICATION: This medication is given by injection into a muscle every 3 to 4 weeks depending on your condition and response. Follow your dosing schedule closely and use this only as directed. Side Effects This may cause nausea, stomach cramping, bloating, breast tenderness, headache and pain or irritation at the injection site. These effects should subside as your body adjusts to the medication. If they continue or become severe, inform your doctor. Notify your doctor if you experience a sudden severe headache, dizziness, jerky muscle movements, vomiting, pain in the calf, chest pain, shortness of breath, menstrual changes, lumps in the breast or breast discharge, vision changes, weakness or tingling in the arms or legs, swelling of lower legs or yellowing of the skin or eyes while using this medication. Contact lens wearers may find their eyes more sensitive or intolerant to the lenses while using this medication. If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Before using this, tell your doctor your entire medical history including your family medical history. Important to note are breast lumps, cancer, abnormal vaginal bleeding, heart, kidney or liver disease, gallbladder disease, high blood pressure, diabetes, blood or blood clotting disorders, epilepsy (seizures), migraine headaches, mental depression or any allergies. This drug should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. This medication may be excreted into breast milk. Consult your doctor before breast-feeding. Cigarette smoking may increase the risk of blood clots from this medication, especially in women over age 35. If you are a smoker, be sure to discuss this with your doctor. Depending on strength, this drug may cause a patchy, darkening of the skin on the face (melasma). Higher strengths are more likely to cause melasma. Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding use of sunscreens and protective clothing. Missed Dose Try to receive each dose as scheduled. If you miss a dose, contact your health care provider to establish a new dosing schedule. Do not "double-up" the dose to catch up. Drug Interactions Tell your doctor of any nonprescription or prescription medication you may take particularly rifampin, blood thinners, antidepressants, barbiturates, steroids, bromocriptine, cyclosporine, liver-toxic drugs (especially dantrolene), seizure medication and of thyroid use. This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.