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Danaparoid is used to prevent harmful blood clots, especially in patients who have had or are having a certain bad reaction to heparin (Heparin-Induced Thrombocytopenia-HIT). Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack. This medication helps keep your blood flowing smoothly by lowering the activity of certain substances in the blood that cause clotting. Danaparoid is an anticoagulant (commonly called a "blood thinner").Conditions that increase your risk of developing blood clots include certain types of surgeries (e.g., hip replacement or abdominal surgery) and long periods of being in one position (immobile). For some medical conditions, danaparoid may be used with other "blood thinners.
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| Overview |
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How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Danaparoid SubQ
Uses
Danaparoid is used to prevent harmful blood clots, especially in patients who have had or are having a certain bad reaction to heparin (Heparin-Induced Thrombocytopenia-HIT). Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack. This medication helps keep your blood flowing smoothly by lowering the activity of certain substances in the blood that cause clotting. Danaparoid is an anticoagulant (commonly called a "blood thinner").Conditions that increase your risk of developing blood clots include certain types of surgeries (e.g., hip replacement or abdominal surgery) and long periods of being in one position (immobile). For some medical conditions, danaparoid may be used with other "blood thinners.
Notes
- Do not share this medication with others.Laboratory and/or medical tests (e.g., blood counts including hemoglobin, hematocrit and platelets, checking stool for blood, blood pressure) should be performed periodically to monitor your progress or check for side effects.
- Additional lab tests (anti-factor Xa blood levels) should be performed in certain cases, especially if you have severe kidney disease, if you are pregnant and have an artificial heart valve, or if the danaparoid does not appear to be working properly.
- Consult your doctor for more details.
Storage
- Store between 36-86 degrees F (2-30 degrees C) away from light and moisture.
- Do not freeze.
- Do not store in the bathroom.
- Keep all medicines away from children and pets.If mixed in the correct IV fluid, this medication should be used within 48 hours if it has been stored at room temperature.
- Otherwise, discard any unused medication.
Overdose
- Symptoms of overdose may include: unusual bleeding and bruising.
How To Use
- This medication is given by injection under the skin (subcutaneously) by a health care professional, usually twice daily following surgery.
- It is important to change the injection site often to limit irritation.
- For some conditions, this medication may be injected directly into a vein by a health care professional.
- This drug should not be injected into a muscle.
- This medication should not be mixed with or added to any other medication in the same syringe.
- Before using, check this product visually for particles or discoloration.
- If either is present, do not use the liquid.Dosage is based on your medical condition, body weight, kidney function, and response to treatment.
- Therapy with this drug may be continued for up to 14 days or until the risk of harmful blood clot formation is reduced.
- Follow your doctor's directions carefully.If you are giving yourself injections at home, make sure you learn how to prepare and inject this medication properly.
- Select a different site for each injection.
- Ask your doctor, pharmacist, or nurse any questions you may have about how to give yourself danaparoid.
- Learn how to properly dispose of used syringes, needles, and any unused medication.
- Never reuse needles or syringes.Use this medication regularly in order to get the most benefit from it.
- Remember to use it at the same times each day.Use this medication exactly as prescribed by your doctor.
- Do not skip any doses.
- It is very important to continue using this medication even if you feel well.
- Do not stop using danaparoid without first talking with your doctor.
Side Effects
- See also Warning section.Nausea, constipation, fever, headache, weakness, or pain/redness/irritation at the injection site may occur.
- If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.This medication can cause bleeding if its effect is too strong.
- Tell your doctor immediately if any of these unlikely but serious signs of bleeding occur: unusual pain/swelling/discomfort, unusual/prolonged bleeding, unusual/easy bruising.Tell your doctor immediately if any of these rare but very serious signs of bleeding occur: dark urine, black stools, severe headache, confusion, vision changes, unusual dizziness, fainting, seizures, weakness, numbness.A very serious allergic reaction to this drug is rare.
- However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before using danaparoid, tell your doctor or pharmacist if you are allergic to it; or to heparins, pork, or sulfites; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
- Before using this medicine, consult your doctor or pharmacist if you have: current serious bleeding.Before using this medication, tell your doctor or pharmacist your medical history, especially of: artificial heart valves, bleeding/blood-clotting disorders, certain eye problems (hemorrhagic or diabetic retinopathy), uncontrolled severe high blood pressure, infection of the heart, kidney disease, liver disease, certain stomach/intestinal problems (e.g., current or recent ulcers), stroke, recent spinal procedures/puncture/surgery, recent eye/ear/brain surgery, asthma.Limit alcohol while taking this drug because it may increase the risk of stomach bleeding.Before having surgery, tell your doctor or dentist that you are using danaparoid.This medication can infrequently cause heavy bleeding.
- Be very careful to avoid injuries (e.g., contact sports).
- Use an electric razor when shaving and a soft toothbrush when brushing your teeth.The elderly may be at greater risk for bleeding while using this drug.During pregnancy, danaparoid should be used only when clearly needed.
- Discuss the risks and benefits with your doctor.
- Pregnant women with artificial heart valves need close monitoring (see Notes).It is not known whether this drug passes into breast milk.
- Consult your doctor before breast-feeding.
Missed Dose
- If you miss a dose, use it as soon as you remember.
- If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
- Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medication because a very serious interaction may occur: mifepristone.If you are currently using this medication, tell your doctor or pharmacist before starting danaparoid.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: sulfinpyrazone.This medication is sometimes used with other drugs that have "blood-thinning" or anti-platelet effects such as acenocoumarol, aspirin, clopidogrel, or warfarin.
- When these combinations are prescribed by your doctor, you will require closer monitoring to lessen your risk of bleeding.
- Keep all medical and laboratory appointments.Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, aspirin) that can increase the risk of bleeding/anti-platelet effect when used with danaparoid.
- Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention or to prevent clotting of artificial heart valves (usually at dosages of 81-325 milligrams per day).
- Consult your doctor or pharmacist for more details.This medication may interfere with certain laboratory tests, possibly causing false test results.
- Make sure laboratory personnel and all your doctors know you use this drug.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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