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Drug Guide    C   Cytarabine

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   Cytarabine

Cytarabine
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Cytarabine is used alone or with other medications to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cancer cell growth.


 
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Overview Photos How To Use Side Effects Precautions Missed Dose Drug Interactions

Cytarabine

Uses
Cytarabine is used alone or with other medications to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cancer cell growth.
Notes
  • Laboratory and/or medical tests (e.g., complete blood counts, liver/kidney function tests) should be performed to monitor your progress or check for side effects.
  • Consult your doctor for more details.

Storage
  • Store unmixed medication vials at room temperature (77 degrees F or 25 degrees C) away from light.
  • Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
  • Once the medication is mixed, ask your pharmacist for storage and expiration information.

Overdose
  • Symptoms of overdose may include confusion, mental/mood changes.

How To Use
  • This medication is usually given by injection into a vein (IV) by a health care professional.
  • It may also be given by other methods of injection depending upon your medical condition.
  • The dosage is based on your medical condition, body size, and response to therapy.This medication should be mixed and diluted in the proper solution.
  • Before using, check this medication visually for particles, haze, or discoloration.
  • If any are present, do not use the liquid.
  • If you have questions regarding the use of this medication, consult your pharmacist.Solutions containing benzyl alcohol should not be used to dilute this medication if cytarabine is given in high doses, to a newborn, or by injection into the spine.Unless your doctor instructs you otherwise, drink plenty of fluids while using this medication.
  • This helps your kidneys remove the drug from your body and may help you avoid some of the side effects.

Side Effects
  • See also the Warning section.Nausea, vomiting, loss of appetite, diarrhea, headache, dizziness, and pain/swelling/redness at the injection site may occur.
  • Nausea and vomiting can be severe.
  • In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting.
  • Not eating before your treatment may help relieve vomiting.
  • Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Temporary hair loss may occur.
  • Normal hair growth should return after treatment has ended.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: fever with body aches, muscle/bone pain, chest pain, eye redness/itching/pain, painful/difficult swallowing, anal sores, change in the amount of urine, painful/difficult urination, joint/side/back pain, pain/redness/swelling of the arms/legs/feet, numbness or tingling of hands/feet, freckling, big toe pain.Tell your doctor immediately if any of these rare but very serious side effects occur: trouble breathing, black/bloody stools, blood in the urine, vomit that looks like coffee grounds, vision problems, mental/mood changes (e.g., confusion), unexplained drowsiness, unconsciousness, enlarged abdomen, trouble walking, muscle weakness, loss of coordination, inability to move (paralysis), seizures.This medication can lower the body's ability to fight an infection.
  • Notify your doctor promptly if you develop any signs of an infection such as fever, chills, unusual cough, or persistent sore throat.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking cytarabine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: decreased bone marrow function/blood cell disorders (e.g., anemia, leukopenia, thrombocytopenia), liver disease, kidney disease, gout.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine.Use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured.Wash your hands well to prevent the spread of infections.This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcoholic beverages.A preservative (benzyl alcohol) which may be found in this product or in the liquid used to mix this product (diluent) can infrequently cause serious problems (sometimes death), if given in large amounts (more than 100 milligrams per kilogram daily) to an infant during the first months of life (neonatal period).
  • The risk is also greater with low birth weight infants.
  • Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat.
  • Report these symptoms to the doctor immediately should they occur.
  • If possible, a preservative-free product should be used when treating neonates.This medication is not recommended for use during pregnancy.
  • It may harm an unborn baby, especially in the first 3 months of pregnancy.
  • Consult your doctor for more details and to discuss reliable forms of birth control.
  • It is recommended that men and women use two effective forms of birth control (e.g., condoms, birth control pills) while taking this medication and for some period afterwards.It is not known whether this drug passes into breast milk.
  • Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • For optimal benefits, it is important to receive each scheduled dose of this medication as directed.
  • If you miss a dose, contact your doctor to establish a new dosing schedule.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, flucytosine, gentamicin.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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