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Drug Guide    C   Chlorambucil

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   Chlorambucil

Chlorambucil
Oral


This medication is used to treat certain types of cancer (e.g., leukemia, lymphoma). Chlorambucil is a chemotherapy drug that works by slowing or stopping cell growth.This drug may also be used for certain blood diseases, certain types of kidney disease in children that have not responded to other treatment, and other conditions as determined by your doctor.


 
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Overview Photos How To Use Side Effects Precautions Missed Dose Drug Interactions

Chlorambucil

Uses
This medication is used to treat certain types of cancer (e.g., leukemia, lymphoma). Chlorambucil is a chemotherapy drug that works by slowing or stopping cell growth.This drug may also be used for certain blood diseases, certain types of kidney disease in children that have not responded to other treatment, and other conditions as determined by your doctor.
Notes
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood counts, uric acid levels) should be performed to monitor your progress or check for side effects.
  • Consult your doctor for more details.
  • It is important that you keep all medical appointments.

Storage
  • Store in a refrigerator between 36-46 degrees F (2-8 degrees C) away from light and moisture.
  • Do not freeze.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include seizures.

How To Use
  • Take this medication by mouth exactly as directed by your doctor.
  • Unless your doctor directs you otherwise, drink plenty of fluids while taking this medication.
  • This will help prevent side effects.The dosage is based on your medical condition, weight, and response to therapy.
  • Do not increase your dose or take this medication more often without your doctor's approval.
  • Your condition will not improve any faster and the risk of serious side effects may be increased.Since this drug can be absorbed through the skin, women who are pregnant or who may become pregnant should not handle or break the tablets of this medication.

Side Effects
  • See also Warnings section.Nausea, vomiting, stomach upset, diarrhea, and loss of appetite may occur.
  • Changes in diet such as eating several small meals or limiting physical activity may help lessen the chance of nausea.
  • In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mouth sores, shaking/tremors, muscle problems (e.g., twitching, stiffness, weakness), unsteadiness, joint pain, lower back pain/side pain, frequent/painful urination, numbness/tingling of the hands or feet, swelling of the legs/feet, mental/mood changes (e.g., confusion, hallucinations), stopping of menstrual periods.Tell your doctor immediately if any of these rare but very serious side effects occur: seizures, trouble breathing, severe stomach/abdominal pain, yellowing of the skin/eyes, dark urine, inability to move arms/legs.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking chlorambucil, tell your doctor or pharmacist if you are allergic to it; or to other chemotherapy drugs (e.g., busulfan, cyclophosphamide); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, head injury, gout, kidney stones, blood disorders (e.g., anemia, neutropenia, thrombocytopenia).Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured.Wash your hands well to prevent the spread of infections.Caution is advised when using this drug in children because they may be more sensitive to its effects, especially possible infertility later in life.
  • Children treated for a certain kidney disease (nephrotic syndrome) may be more at risk for seizures.This drug is not recommended for use during pregnancy.
  • It may cause harm to an unborn baby.
  • Women of childbearing age and men should use reliable form(s) of birth control during treatment with this drug.
  • Consult your doctor for more details.It is not known whether this drug passes into breast milk.
  • Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • It is important you receive each scheduled dose of this medication as directed.
  • If you miss a dose, contact your doctor to establish a new dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because very serious interactions may occur: nalidixic acid.If you are currently using the medication listed above, tell your doctor or pharmacist before starting chlorambucil.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with chlorambucil such as isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline), among others.
  • Consult your doctor or pharmacist for details.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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