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Drug Guide    C   CLOLAR

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   CLOLAR

CLOLAR
IV


Clofarabine is used to treat a certain type of cancer (acute lymphoblastic leukemia-ALL) in children and young adults ages 1 to 21 whose cancer has not been successfully treated by at least 2 other treatments. It works by stopping the growth of cancer cells.



 
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 CLOLAR images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions



CLOLAR

Uses
Clofarabine is used to treat a certain type of cancer (acute lymphoblastic leukemia-ALL) in children and young adults ages 1 to 21 whose cancer has not been successfully treated by at least 2 other treatments. It works by stopping the growth of cancer cells.
Notes
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood counts, kidney function, liver function, bilirubin blood levels, blood pressure, lung function) should be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.

Storage
  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
  • After mixing, the medication may be stored at room temperature but should be used within 24 hours.
  • Discard any unused medication.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.


How To Use
  • This medication is given by injection into a vein by a health care professional.
  • Follow all instructions for proper mixing with the correct IV fluid.
  • Do not mix clofarabine with other medications in the same solution or give together in the same IV line.
  • Clean the injection site with rubbing alcohol before giving this medication.
  • Before using, check this product visually for particles or discoloration.
  • If either is present, do not use the solution.
  • If you have any questions about the preparation or use of this medication, consult your pharmacist.Drink plenty of fluids to prevent serious problems due to a loss of too much body water (dehydration).Dosage is based on your medical condition, body size, and response to treatment.
  • This medication is usually given over 2 hours once a day for 5 days in a row or as directed by your doctor.
  • A 5-day course of this medication is called a cycle.
  • This cycle is repeated every 2 to 6 weeks depending on your response.Use care when preparing or giving this medication.
  • Avoid getting the medication on the skin or in the eyes, mouth, or nose.
  • If you do get the medication in those areas, flush with plenty of water and tell your doctor immediately.

Side Effects
  • Pain at the injection site, tiredness, flushing, headache, dizziness, lightheadedness, fainting, drowsiness, back pain, stomach pain, diarrhea, nausea, vomiting, and loss of appetite may occur.
  • Nausea and vomiting can be severe.
  • In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.
  • Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects.
  • If these effects persist or worsen, tell your doctor or pharmacist promptly.Many people using this medication have serious side effects.
  • However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Careful monitoring by your doctor may decrease your risk.Treatment with clofarabine may sometimes cause your hands/feet to develop a skin reaction called hand-foot syndrome (palmar-plantar erythrodysesthesia).
  • You can prevent or reduce these problems by protecting your hands and feet from a great deal of heat or pressure.
  • Avoid unnecessary exposure to heat (e.g., hot dishwater, long hot baths).
  • Avoid pressure on elbows, knees, and soles of feet (e.g., leaning on elbows, kneeling, taking long walks).
  • Wear loose clothing.
  • Depending on how severe your hand-foot syndrome is, your doctor may prescribe a medication to reduce the symptoms or decrease/delay your next dose of clofarabine.
  • If you experience pain/swelling/redness, blisters, or numbness of the hands/feet that affects your usual activities, tell your doctor immediately.Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bleeding/bruising, muscle/joint pain, lack of urine, swelling feet/ankles, mental/mood changes (e.g., anxiety, depression), dark urine, yellowing skin/eyes, fast/difficult breathing, fast heartbeat.This medication can lower the body's ability to fight an infection.
  • Tell your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.Clofarabine sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome).
  • To lower your risk, drink plenty of fluids unless your doctor directs you otherwise.
  • Tell your doctor immediately if you experience symptoms such as low back/side pain (flank pain), red/pinkish urine, painful urination, or muscle spasms/weakness.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking clofarabine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (e.g., bone marrow suppression), kidney disease, liver disease, recent/current infections.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.
  • Wash your hands well to prevent the spread of infections.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.This drug may make you dizzy or drowsy.
  • Use caution while driving, using machinery, or taking part in any other activity that requires alertness.
  • Limit alcoholic beverages.This drug is not recommended for use during pregnancy.
  • It may harm the unborn baby.
  • If you become pregnant or think you may be pregnant, tell your doctor immediately.
  • Males and females must use 2 reliable forms of birth control (e.g., condoms and birth control pills) during treatment with this drug.
  • Talk with your doctor about effective forms of birth control.It is not known whether this drug passes into breast milk.
  • Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • For the best possible benefit, it is important to receive each scheduled dose of this medication as directed.
  • If you miss a dose, contact your doctor to establish a new dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: live vaccines (e.g., flu vaccine inhaled through the nose, typhoid/polio vaccine taken by mouth).If you have recently used or are planning to use any of these medications, tell your doctor or pharmacist before starting clofarabine.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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