AzathioprineOral - Drug Information and Side Effects on Drug3k.com


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Azathioprine images:

Overview

Photos

How To Use

Side Effects

Precautions

Missed Dose

Drug Interactions

Azathioprine

Uses
Azathioprine is used with other medications to prevent rejection of a kidney transplant. It works by weakening your body's defense system (immune system) to help your body accept the new kidney as if it were your own. This medication belongs to a class of drugs known as immunosuppressants.Azathioprine is also used to treat patients with severe rheumatoid arthritis who have not responded to other medications (e.g., nonsteroidal anti-inflammatory drugs/NSAIDs such as ibuprofen). Rheumatoid arthritis is thought to be caused by the immune system attacking the joints. Early treatment of rheumatoid arthritis with more aggressive therapy such as azathioprine helps to reduce further joint damage and to preserve joint function.This medication may also be used to prevent rejection of other transplanted organs, to treat a certain type of bowel condition (Crohn's disease) that is not responsive to usual treatment, and to treat other immune system problems (autoimmune diseases) as determined by your doctor.
Notes

Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count, liver and kidney function) should be performed periodically to monitor your progress or check for side effects.
Consult your doctor for more details.If you have had an organ transplant, it is recommended that you attend a transplant education class or support group.
Learn the signs of organ rejection such as a feeling of being ill, fever, or tenderness around the transplanted organ.
Signs of a failing kidney transplant include a decrease in the amount of urine, swelling of the arms/legs/face, trouble breathing, or increase in blood pressure.
Seek immediate medical attention if these symptoms occur.

Storage

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture.
Do not store in the bathroom.
Keep all medicines away from children and pets.

How To Use

Take this medication by mouth, usually once or twice daily as directed by your doctor.
Azathioprine should be taken with food to reduce stomach upset.
Dosage is based on your medical condition, weight, and response to therapy.
For the treatment of rheumatoid arthritis, the manufacturer recommends that you do not take more than 2.5 milligrams per kilogram per day.Do not increase your dose or take this medication more often without your doctor's approval.
Your condition will not improve any faster and the risk of serious side effects may be increased.
Also do not stop taking this medication without your doctor's approval.Use this medication regularly in order to get the most benefit from it.
Remember to use it at the same time(s) each day.For arthritis, it may take up to 2 months of continued use to notice relief of symptoms.
Inform your doctor if your condition does not improve after 3 months of treatment.Since this drug can be absorbed through the skin, women who are pregnant or who may become pregnant should not handle or break the tablets of this medication.

Side Effects

See also Warning section.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.You may experience stomach/intestinal symptoms such as nausea, vomiting, diarrhea, or loss of appetite.
If these effects persist or worsen, notify your doctor immediately.
These symptoms may be reduced by taking the medication after meals.
Talk to your doctor or pharmacist about other dosing advice that may also help with these symptoms.Although unlikely, more severe stomach/intestinal symptoms (e.g., severe nausea/vomiting/diarrhea, stomach/abdominal pain) may occur as part of a very serious allergic reaction.
Seek immediate medical attention if you have severe stomach/intestinal symptoms or other symptoms of a serious allergic reaction which may include: fever, shaking chills, rash, itching, swelling, severe dizziness, trouble breathing, cough, new or worsening joint/muscle aches, dark urine.Tell your doctor immediately if any of these unlikely but serious side effects occur: weakness, muscle loss, vision changes, hair loss, cold/numbness in the fingers, mouth sores, difficult/painful swallowing, greasy stools.Seek immediate medical attention if any of these rare but very serious side effects occur: yellowing eyes/skin, swelling/extra fluid around the abdomen, vomit that contains blood or looks like coffee grounds, black stools.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before taking azathioprine, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, blood disorders, decreased bone marrow function, cancer, active infections, certain enzyme disorder (TPMT deficiency).Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received polio vaccine by mouth or flu vaccine inhaled through the nose.Since this medication can increase your risk of developing serious infections, wash your hands well to prevent the spread of infections.
Avoid contact with people who have illnesses that may spread to others (e.g., flu, chickenpox).Use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.Kidney function declines as you grow older.
This medication is removed by the kidneys.
Therefore, the elderly may be more sensitive to the effects of this drug.This medication is not recommended for use during pregnancy.
It may harm an unborn baby.
Consult your doctor for more details.
It is recommended that men and women use two effective forms of birth control (e.g., condoms, birth control pill) while taking this medication.
However, this medication can decrease the effectiveness of intrauterine devices (IUDs).
This can result in pregnancy.
Talk to your doctor about other effective birth control choices.This medication passes into breast milk and may have undesirable effects on a nursing infant.
Therefore, breast-feeding while using this drug is not recommended.
Consult your doctor before breast-feeding.

Missed Dose

Unless your doctor directs you otherwise, if you take this drug once daily and miss a dose, take it as soon as you remember unless it is almost time for the next dose.
If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
Do not double the dose to catch up.If you take more than one dose a day and miss a dose, take it as soon as you remember.
If it is almost time for the next dose, take both doses together, then resume your usual dosing schedule.
If you miss more than one dose, contact your doctor.
You may need to have your dosing schedule adjusted.

Drug Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: past or present use of alkylating-type cancer drugs (e.g., chlorambucil, cyclophosphamide, melphalan), mercaptopurine, natalizumab.If you are currently using or have used any of these medications listed above, tell your doctor or pharmacist before starting azathioprine.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: ACE inhibitors (e.g., benazepril, lisinopril), allopurinol, aminosalicylates (e.g., olsalazine, sulfasalazine), "blood thinners" (e.g., enoxaparin, heparin, warfarin), drugs affecting the bone marrow (e.g., trimethoprim/sulfamethoxazole, cancer chemotherapy drugs).

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.