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Drug Guide    D   Diclofenac/misoprostol

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   Diclofenac/misoprostol

Diclofenac/misoprostol
(oral) (tablet, Tablet, Enteric Coated)


Treats pain caused by arthritis in people who might have stomach problems caused by pain medicine. This medicine is a combination of a non-steroidal anti-inflammatory drug (NSAID) and a prostaglandin that helps to protect against ulcers in your stomach or intestines.

ALTERNATE NAMES

Arthrotec, Arthrotec 75

 
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Overview Photos How To Use Side Effects Precautions Missed Dose Drug Interactions

Diclofenac/misoprostol
Arthrotec, Arthrotec 75
Uses
Treats pain caused by arthritis in people who might have stomach problems caused by pain medicine. This medicine is a combination of a non-steroidal anti-inflammatory drug (NSAID) and a prostaglandin that helps to protect against ulcers in your stomach or intestines.

Storage
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed. Keep all medicine away from children and never share your medicine with anyone.
  • If a pregnant woman takes this medicine, she could have a miscarriage with serious problems.


How To Use
  • APPEARANCE: Tablet, Coated Tablet. Your doctor will tell you how much of this medicine to use and how often.
  • Do not use more medicine or use it more often than your doctor tells you to. This medicine should come with a Medication Guide.
  • Read and follow these instructions carefully.
  • Ask your doctor or pharmacist if you have any questions.
  • Ask your pharmacist for the Medication Guide if you do not have one.
  • Your doctor might ask you to sign some forms to show that you understand this information. It is best to take this medicine with food or milk, to limit diarrhea and so it does not upset your stomach. Swallow the tablet whole with a full glass of water.
  • Do not crush, break, or chew it. If you are able to become pregnant, you might need to have a negative pregnancy test before you start using this medicine.
  • Also, you might need to start using this medicine only on the second or third day of a normal menstrual period. Use this medicine for the shortest time possible and in the smallest dose possible.
  • This will help lower the risk of side effects. You might also be given another pill that contains only diclofenac or misoprostol, if this combination tablet does not have enough of one of the medicines.
  • Take all medicines that are prescribed.

Side Effects
  • Call your doctor right away if you notice any of these side effects: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. Bleeding from your vagina. Blistering, peeling, red skin rash. Bloody or black, tarry stools. Chest pain, shortness of breath, or coughing up blood. Change in how much or how often you urinate. Flu-like symptoms Nausea, vomiting, loss of appetite, pain in your upper stomach. Neck pain, fever. Numbness or weakness in your arm or leg, or on one side of your body. Pain in your lower leg (calf). Problems with vision, speech, or walking. Severe stomach pain, severe or ongoing diarrhea. Shortness of breath, cold sweat, and bluish-colored skin. Sudden or severe headache. Swelling in your hands, ankles, or feet. Unexplained weight gain. Unusual bleeding or bruising. Unusual vaginal bleeding. Vomiting blood or material that looks like coffee grounds. Yellowing of your skin or the whites of your eyes.

Precautions
  • You should not use this medicine if you have had an allergic reaction (including asthma) to diclofenac, misoprostol, or similar medicines.
  • Some other NSAID medicines are aspirin, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Ecotrin®, Motrin®, or Votaren®.
  • Some other prostaglandin medicines are alprostadil, epoprostenol, iloprost, latanoprost, Caverject®, Flolan®, Muse®, Prostin®, Ventavis®, and Xalatan®.
  • Do not use this medicine if you are pregnant or are trying to get pregnant.
  • You must be able to use birth control measures.
  • Do not use this medicine right before or right after having coronary artery bypass graft (CABG), a type of heart surgery.

Missed Dose
  • If you miss a dose or forget to use your medicine, use it as soon as you can.
  • If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.

Drug Interactions
  • Using this medicine while you are pregnant can harm your unborn baby.
  • Use an effective form of birth control to keep from getting pregnant.
  • If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Continue to use birth control for at least one month after you stop using this medicine.
  • Your doctor may want you to have a pregnancy test to be sure you are not pregnant before you start using this medicine. Make sure your doctor knows if you are breast feeding. Make sure your doctor knows if you have high blood pressure, congestive heart failure (CHF), or other heart or circulation problems.
  • Tell your doctor if you have asthma, kidney disease, liver disease, diabetes, a bleeding problem, or porphyria.
  • Make sure your doctor knows if you have a digestion problem (such as inflammatory bowel disease) or lupus or similar connective tissue disease. This medicine may raise your risk of having a heart attack or stroke.
  • This is more likely in people who already have heart disease.
  • People who use this medicine for a long time might also have a higher risk. This medicine might cause bleeding in your stomach or intestines.
  • This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner). Your doctor will need to check your blood or urine at regular visits while you are using this medicine.
  • Be sure to keep all appointments. Make sure any doctor or dentist who treats you knows that you are using this medicine.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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