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Pegademase is used to treat a certain rare genetic immune system problem (severe combined immune deficiency disease-SCID). Pegademase replaces a certain natural substance (an enzyme called adenosine deaminase-ADA) that is missing in people with SCID. This medication increases the number of blood cells that prevent and fight infection (lymphocytes) by helping the body get rid of certain substances that kill lymphocytes.This medication does not help immune system problems due to other causes (e.g., AIDS, bone marrow depression).
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| Overview |
Photos |
How To Use |
Side Effects |
Precautions |
Missed Dose |
Drug Interactions |
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Adagen IM
Uses
Pegademase is used to treat a certain rare genetic immune system problem (severe combined immune deficiency disease-SCID). Pegademase replaces a certain natural substance (an enzyme called adenosine deaminase-ADA) that is missing in people with SCID. This medication increases the number of blood cells that prevent and fight infection (lymphocytes) by helping the body get rid of certain substances that kill lymphocytes.This medication does not help immune system problems due to other causes (e.g., AIDS, bone marrow depression).
Notes
- Do not share this product with others.Laboratory and/or medical tests (e.g., plasma ADA levels, red blood cell dATP levels) should be performed periodically to monitor your progress or check for side effects.
- Consult your doctor for more details.
Storage
- Store in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light and moisture.
- Do not freeze.
- Do not use the liquid if it has been frozen.
- Do not store at room temperature.
- Keep all medicines away from children and pets.Discard any unused liquid after opening the vial.
- Do not re-use the vial after opening.
- Do not save unused liquid for later use.
How To Use
- This medication is injected into a muscle by a health care professional, usually once a week or as directed by your doctor.Learn all preparation and usage instructions in the product package.
- If any of the information is unclear, consult your doctor or pharmacist.Before using, check this product visually for particles or discoloration.
- If either is present, do not use the liquid.
- Do not mix this medication with any other medication/solution in the same injection.The dosage is based on your medical condition, weight, and response to treatment.
- This medication must be used as scheduled to maintain the proper enzyme level.
- Your doctor will order frequent blood tests to monitor your response and find the best dose for you.
- Keep all medical/lab appointments.Your immune system will usually improve slowly, and you should have fewer/less severe infections in 2 to 6 months.
Side Effects
- Bleeding/bruising/pain at the injection site and headache may occur.
- If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
- Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare.
- However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
- Before using pegademase, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: clotting problems (e.g., low blood platelets).This medication may take several weeks or months to work.
- You may continue to be at an increased risk of infection even after the medication is working.
- Follow all of your doctor's advice for preventing infection.
- Wash your hands well, and avoid contact with people who currently have an infection.During pregnancy, this medication should be used only when clearly needed.
- Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk.
- Consult your doctor before breast-feeding.
Missed Dose
- It is important to receive each scheduled dose of this medication as directed.
- Keep all your medical/lab appointments.
- If you miss a dose, contact your doctor to establish a new dosing schedule.
- Do not double the dose to catch up.
Drug Interactions
- Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
- Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: vidarabine.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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